Trifasciatosides A-J, Steroidal Saponins from Sansevieria trifasciata

被引：22

作者：

Teponno, Remy Bertrand ^{[1
,2
]}

Tanaka, Chiaki ^{[2
]}

Jie, Bai ^{[2
]}

Tapondjou, Leon Azefack ^{[1
]}

Miyamoto, Tomofumi ^{[2
]}

机构：

[1] Univ Dschang, Dept Chem, Fac Sci, POB 67, Dschang, Cameroon

[2] Kyushu Univ, Grad Sch Pharmaceut Sci, Dept Nat Prod Chem, Fukuoka 8128582, Japan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2016年 / 64卷 / 09期

关键词：

Sansevieria trifasciata; Dracaenaceae; steroidal saponin; antiproliferative activity; NMR-SPECTROSCOPY; PLANT SAPONINS; GLYCOSIDES; DRACAENA; SAPOGENINS; SEPARATION; RHIZOMES; LEAVES; FRUITS;

D O I：

10.1248/cpb.c16-00337

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Four previously unreported steroidal saponins, trifasciatosides A-D (1-4), three pairs of previously undescribed steroidal saponins, trifasciatosides E-J (5a, b-7a, b) including acetylated ones, together with twelve known compounds were isolated from the n-butanol soluble fraction of the methanol extract of Sansevieria trifasciata. Their structures were elucidated on the basis of detailed spectroscopic analysis, including H-1-NMR, C-13-NMR, H-1-H-1 correlated spectroscopy (COSY), heteronuclear single quantum coherence (HSQC), heteronuclear multiple bond connectivity (HMBC), total correlated spectroscopy (TOCSY), nuclear Overhauser enhancement and exchange spectroscopy (NOESY), electrospray ionization-time of flight (ESI-TOF)-MS and chemical methods. Compounds 2, 4, and 7a, b exhibited moderate antiproliferative activity against HeLa cells.

引用

页码：1347 / 1355

页数：9

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