Mitochondrial DNA alterations and reduced mitochondrial function in aging

被引：71
|
作者：
Hebert, Sadie L. [1 ]
Lanza, Ian R. [1 ]
Nair, K. Sreekumaran [1 ]
机构：
[1] Mayo Clin, Endocrine Res Unit, Rochester, MN 55905 USA
来源：
MECHANISMS OF AGEING AND DEVELOPMENT | 2010年 / 131卷 / 7-8期
关键词：
Aging; Mitochondria; Mitochondrial DNA; HUMAN SKELETAL-MUSCLE; MULTIPLE MTDNA DELETIONS; MYOSIN HEAVY-CHAIN; IN-VIVO; POINT MUTATIONS; PROTEIN-SYNTHESIS; OXIDATIVE STRESS; UNCOUPLING PROTEIN-3; ENDURANCE EXERCISE; GENE-EXPRESSION;
D O I：
10.1016/j.mad.2010.03.007
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Oxidative damage to mitochondrial DNA increases with aging. This damage has the potential to affect mitochondrial DNA replication and transcription which could alter the abundance or functionality of mitochondrial proteins. This review describes mitochondria! DNA alterations and changes in mitochondrial function that occur with aging. Age-related alterations in mitochondrial DNA as a possible contributor to the reduction in mitochondrial function are discussed. (c) 2010 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：451 / 462
页数：12
相关论文
共 50 条
  • [41] Mitochondrial DNA repair in aging and disease
    Druzhyna, Nadiya M.
    Wilson, Glenn L.
    LeDoux, Susan P.
    MECHANISMS OF AGEING AND DEVELOPMENT, 2008, 129 (7-8) : 383 - 390
  • [42] The timing of mitochondrial DNA mutations in aging
    Khrapko, Konstantin
    NATURE GENETICS, 2011, 43 (08) : 726 - 727
  • [43] Mitochondrial DNA mutations in disease and aging
    Park, Chan Bae
    Larsson, Nils-Goeran
    JOURNAL OF CELL BIOLOGY, 2011, 193 (05): : 809 - 818
  • [44] Mitochondrial DNA Mutations in Disease and Aging
    Wallace, Douglas C.
    ENVIRONMENTAL AND MOLECULAR MUTAGENESIS, 2010, 51 (05) : 440 - 450
  • [45] Mitochondrial DNA in aging and degenerative disease
    Berdanier, CD
    Everts, HB
    MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 2001, 475 (1-2) : 169 - 184
  • [46] Repair of mitochondrial DNA in aging and carcinogenesis
    Mark Berneburg
    York Kamenisch
    Jean Krutmann
    Photochemical & Photobiological Sciences, 2006, 5 : 190 - 198
  • [47] Role of mitochondrial DNA in human aging
    Attardi, G
    MITOCHONDRION, 2002, 2 (1-2) : 27 - 37
  • [48] Mitochondrial DNA deletions and the aging heart
    Mohamed, SA
    Hanke, T
    Erasmi, AW
    Bechtel, MJF
    Scharfschwerdt, M
    Meissner, C
    Sievers, HH
    Gosslau, A
    EXPERIMENTAL GERONTOLOGY, 2006, 41 (05) : 508 - 517
  • [49] Mitochondrial DNA deletions and differential mitochondrial DNA content in Rhesus monkeys: Implications for aging
    Mao, Peizhong
    Gallagher, Patience
    Nedungadi, Samira
    Manczak, Maria
    Shirendeb, Ulziibat P.
    Kohama, Steven G.
    Ferguson, Betsy
    Park, Byung S.
    Reddy, P. Hemachandra
    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 2012, 1822 (02): : 111 - 119
  • [50] MITOCHONDRIAL-FUNCTION IN NEURODEGENERATION AND AGING
    SCHAPIRA, AHV
    COOPER, JM
    MUTATION RESEARCH, 1992, 275 (3-6): : 133 - 143
12345