Mitochondrial DNA alterations and reduced mitochondrial function in aging

被引：71
|
作者：
Hebert, Sadie L. [1 ]
Lanza, Ian R. [1 ]
Nair, K. Sreekumaran [1 ]
机构：
[1] Mayo Clin, Endocrine Res Unit, Rochester, MN 55905 USA
来源：
MECHANISMS OF AGEING AND DEVELOPMENT | 2010年 / 131卷 / 7-8期
关键词：
Aging; Mitochondria; Mitochondrial DNA; HUMAN SKELETAL-MUSCLE; MULTIPLE MTDNA DELETIONS; MYOSIN HEAVY-CHAIN; IN-VIVO; POINT MUTATIONS; PROTEIN-SYNTHESIS; OXIDATIVE STRESS; UNCOUPLING PROTEIN-3; ENDURANCE EXERCISE; GENE-EXPRESSION;
D O I：
10.1016/j.mad.2010.03.007
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Oxidative damage to mitochondrial DNA increases with aging. This damage has the potential to affect mitochondrial DNA replication and transcription which could alter the abundance or functionality of mitochondrial proteins. This review describes mitochondria! DNA alterations and changes in mitochondrial function that occur with aging. Age-related alterations in mitochondrial DNA as a possible contributor to the reduction in mitochondrial function are discussed. (c) 2010 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：451 / 462
页数：12
相关论文
共 50 条
  • [31] Mitochondrial DNA Alterations in Glioblastoma (GBM)
    Leao Barros, Mariceli Baia
    Pinheiro, Danilo do Rosario
    Borges, Barbara do Nascimento
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (11)
  • [32] Cadmium hepatotoxicity and alterations of the mitochondrial function
    Al-Nasser, IA
    JOURNAL OF TOXICOLOGY-CLINICAL TOXICOLOGY, 2000, 38 (04): : 407 - 413
  • [33] Somatic alterations in mitochondrial DNA and mitochondrial dysfunction in gastric cancer progression
    Lee, Hsin-Chen
    Huang, Kuo-Hung
    Yeh, Tien-Shun
    Chi, Chin-Wen
    WORLD JOURNAL OF GASTROENTEROLOGY, 2014, 20 (14) : 3950 - 3959
  • [34] Alterations of the mitochondrial proteome caused by the absence of mitochondrial DNA: A proteomic view
    Chevallet, Mireille
    Lescuyer, Pierre
    Diemer, Helene
    van Dorsselaer, Alain
    Leize-Wagner, Emmanuelle
    Rabilloud, Thierry
    ELECTROPHORESIS, 2006, 27 (08) : 1574 - 1583
  • [35] Somatic alterations in mitochondrial DNA and mitochondrial dysfunction in gastric cancer progression
    Hsin-Chen Lee
    Kuo-Hung Huang
    Tien-Shun Yeh
    Chin-Wen Chi
    World Journal of Gastroenterology, 2014, 20 (14) : 3950 - 3959
  • [36] Mitochondrial function and mitochondrial DNA maintenance with advancing age
    Azhub I. Gaziev
    Serzh Abdullaev
    Andrej Podlutsky
    Biogerontology, 2014, 15 : 417 - 438
  • [37] Mitochondrial and nuclear DNA in healthy aging
    Enriquez, J. A.
    Lehuga-Vieco, A. V.
    Latorre-Pellicer, A.
    Acin-Perez, R.
    Calvo, E.
    Ruiz-Cabello, J.
    Vazquez, J.
    EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 2018, 48 : 30 - 30
  • [38] Mitochondrial function and mitochondrial DNA maintenance with advancing age
    Gaziev, Azhub I.
    Abdullaev, Serzh
    Podlutsky, Andrej
    BIOGERONTOLOGY, 2014, 15 (05) : 417 - 438
  • [39] The timing of mitochondrial DNA mutations in aging
    Konstantin Khrapko
    Nature Genetics, 2011, 43 : 726 - 727
  • [40] Repair of mitochondrial DNA in aging and carcinogenesis
    Berneburg, M
    Kamenisch, Y
    Krutmann, J
    PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES, 2006, 5 (02) : 190 - 198
12345