Mitochondrial DNA alterations and reduced mitochondrial function in aging

被引：71
|
作者：
Hebert, Sadie L. [1 ]
Lanza, Ian R. [1 ]
Nair, K. Sreekumaran [1 ]
机构：
[1] Mayo Clin, Endocrine Res Unit, Rochester, MN 55905 USA
来源：
MECHANISMS OF AGEING AND DEVELOPMENT | 2010年 / 131卷 / 7-8期
关键词：
Aging; Mitochondria; Mitochondrial DNA; HUMAN SKELETAL-MUSCLE; MULTIPLE MTDNA DELETIONS; MYOSIN HEAVY-CHAIN; IN-VIVO; POINT MUTATIONS; PROTEIN-SYNTHESIS; OXIDATIVE STRESS; UNCOUPLING PROTEIN-3; ENDURANCE EXERCISE; GENE-EXPRESSION;
D O I：
10.1016/j.mad.2010.03.007
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Oxidative damage to mitochondrial DNA increases with aging. This damage has the potential to affect mitochondrial DNA replication and transcription which could alter the abundance or functionality of mitochondrial proteins. This review describes mitochondria! DNA alterations and changes in mitochondrial function that occur with aging. Age-related alterations in mitochondrial DNA as a possible contributor to the reduction in mitochondrial function are discussed. (c) 2010 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：451 / 462
页数：12
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