Protective effects of Schisandrin B on cigarette smoke-induced airway injury in mice through Nrf2 pathway

被引：20

作者：

Jia, Ruichun ^{[1
]}

Zhang, Haogang ^{[2
]}

Yang, Zhiping ^{[1
]}

Zhao, Hong ^{[1
]}

Liu, Fei ^{[1
]}

Wang, Hui ^{[1
]}

Miao, Meijuan ^{[1
]}

Wang, Qiushi ^{[3
]}

Liu, Yanhong ^{[4
]}

机构：

[1] Harbin Med Univ, Dept Blood Transfus, Affiliated Hosp 2, Harbin 150081, Heilongjiang, Peoples R China

[2] Harbin Med Univ, Dept Gen Surg, Affiliated Hosp 2, Harbin 150081, Heilongjiang, Peoples R China

[3] Harbin Med Univ, Dept Thorac Surg, Affiliated Hosp 2, Harbin 150081, Heilongjiang, Peoples R China

[4] Harbin Med Univ, Dept Clin Lab, Affiliated Hosp 2, Harbin 150081, Heilongjiang, Peoples R China

来源：

INTERNATIONAL IMMUNOPHARMACOLOGY | 2017年 / 53卷

关键词：

Schisandrin B; Cigarette smoke; Lung inflammation; NF-kappa B; Nrf-2; OBSTRUCTIVE PULMONARY-DISEASE; STRESS-RESPONSE MECHANISM; OXIDATIVE STRESS; LUNG INJURY; KAPPA-B; INFLAMMATION; COPD; EXPRESSION; SUPPRESSES; ACTIVATION;

D O I：

10.1016/j.intimp.2017.09.030

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Schisandrin B (SchB), a dibenzocyclooctadiene derivative isolated from Schisandra chinensis, has been reported to have anti-inflammatory effects. However, the protective effects of SchB on cigarette smoke (CS)-induced lung inflammation remain unclear. This study was to investigate the effects of SchB on CS-induced lung inflammation in mice. The mice were exposed to CS to develop lung inflammation. SchB was given 1 h before CS exposure daily for five consecutive days. The levels of inflammatory mediators TNF-alpha, IL-1 beta, and IL-6 in bronchoalveolar lavage fluid (BALF) were measured in this study. SOD, GSH, MPO and MDA contents were also detected. Furthermore, the expression of Nrf-2 and NF-kappa B were detected by western blot analysis. Histopathological analyses showed that SchB had protective effects against CS-induced lung inflammation. The levels of inflammatory mediators TNF-alpha, IL-1 beta, and IL-6 in BALF were also inhibited by SchB. CS-induced MPO activity and MDA content were inhibited by SchB. The levels of SOD and GSH were up-regulated by SchB. SchB significantly inhibited CS-induced NF-kappa B activation and up-regulated the expression of Nrf2 and HO-1. In conclusion, these data suggest that SchB protects against CS-induced lung inflammation by activating Nrf2 and inhibiting NF-kappa B signaling pathway.

引用

页码：11 / 16

页数：6

共 30 条

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