Enantioseparation of 15 organic phosphonate esters on the cellulose tris(3,5-dimethylphenyl carbamate) chiral stationary phase by HPLC

被引：16

作者：

Du, W

Yang, GS ^{[1
]}

Wang, XQ

Yuan, SL

Zhou, L

Xu, D

Liu, CP

机构：

[1] Shandong Univ, Sch Chem & Chem Engn, Jinan 250100, Peoples R China

[2] Shandong Univ, State Key Lab Crystal Mat, Jinan 250100, Peoples R China

[3] Shandong Univ, Inst Crystal Mat, Jinan 250100, Peoples R China

[4] Inst Vet Drug Control, Jinan 250022, Shandong, Peoples R China

来源：

TALANTA | 2003年 / 60卷 / 06期

基金：

中国国家自然科学基金;

关键词：

enantioseparation; organic phosphonate esters; chiral OD; QSAR;

D O I：

10.1016/S0039-9140(03)00231-5

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A series of 15 organic phosphonate esters enatiomers containing a carbon atom as a chiral center have been separated on the cellulose tris(3,5-dimethylphenyl carbamate) chiral stationary phase (CSP) in the normal phase by high performance liquid chromatography (HPLC). Both the capacity factor (k) and separation factor (alpha) of all solutes are presented. The influence of the substitutional group on the benzene ring attached to the chiral carbon atom and the steric hindrance of alkoxyl of the phosphonate ester on the chiral separation are discussed. Based on a and different structure parameters, good agreement between the predicted values and the experimental ones is obtained. The most characteristic parameter influencing the chromatographic separation is chosen from many structure parameters by linear regression method of QSAR software. The probable mechanism of the chiral recognition is proposed. (C) 2003 Elsevier B.V. All rights reserved.

引用

收藏

页码：1187 / 1195

页数：9

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