Cytokines as emerging targets in the treatment of heart failure

被引：49
作者：
Baumgarten, G
Knuefermann, P
Mann, DL
机构：
[1] VA Med Ctr, Dept Med, Winters Ctr Heart Failure Res, Cardiol Sect, Houston, TX 77030 USA
[2] Baylor Coll Med, Houston, TX 77030 USA
来源：
TRENDS IN CARDIOVASCULAR MEDICINE | 2000年 / 10卷 / 05期
关键词：
D O I：
10.1016/S1050-1738(00)00063-3
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Recent studies have identified the importance of biologically active molecules such as neurohormones in disease progression in heart failure. More recently it has become apparent that in addition to neurohormones another portfolio of biologically active molecules termed cytokines are also expressed in the setting of heart failure. This article reviews recent clinical and experimental material which suggest that the cytokines such as tumor necrosis factor (TNF), interleukin-1 (IL-1) and interleukin-6 (IL-6) may represent another class of biologically active molecules that are responsible for the development and progression of heart failure. In addition, we also review the early results from clinical trials that have utilized various targeted anti-cytokine strategies in patients with heart failure. (C) 2001, Elsevier Science Inc.
引用
收藏
页码：216 / 223
页数：8
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