Supramolecular assembly of photofunctional dendrimers for biomedical nano-devices

被引：25
作者：
Jang, Woo-Dong
Nishiyama, Nobuhiro
Kataoka, Kazunori
机构：
[1] Yonsei Univ, Coll Sci, Dept Chem, Seoul 120749, South Korea
[2] Univ Tokyo, Ctr Dis Biol & Integrat Med, Bunkyo Ku, Tokyo 1138656, Japan
[3] Univ Tokyo, Ctr Nanobio Integrat, Bunkyo Ku, Tokyo 1138656, Japan
[4] Univ Tokyo, Grad Sch Engn, Dept Mat Engn, Bunkyo Ku, Tokyo 1138656, Japan
[5] Japan Sci & Technol Agcy, CREST, Tsukuba, Ibaraki 3058562, Japan
来源：
SUPRAMOLECULAR CHEMISTRY | 2007年 / 19卷 / 4-5期
关键词：
dendrimer; porphyrin; photodynamic therapy; polyion complex micelle;
D O I：
10.1080/10610270701324089
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Recently, dendrimers are attracting much attention for their development as biomedical nano-devices. In the present paper, we introduce dendrimer photosensitizers, composed of a focal photosensitizing unit surrounded by poly(benzyl ether) dendritic wedges, for photodynamic therapy (PDT). Ionic dendritic porphyrins (DPs) formed supramolecular polyion complex (PIC) micelles through the electrostatic interaction with oppositely charged block copolymers, and showed no self-quenching effect of the focal photosensitizing unit due to the large dendritic wedges. The DP-loaded PIC micelles showed selective accumulation to the ophthalmic neovascular lesion and effective photodynamic effect. For the effective light delivery, dendrimer phthalocyanine (DPc) has also been developed and examined for its photodynamic effect.
引用
收藏
页码：309 / 314
页数：6
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