Zinc release of Zn7-metallothionein-3 induces fibrillar type amyloid-β aggregates

被引：30
|
作者：
Durand, Jade [1 ,2 ]
Meloni, Gabriele [3 ]
Talmard, Christine [1 ,2 ]
Vasak, Milan [3 ]
Faller, Peter [1 ,2 ]
机构：
[1] CNRS, LCC, F-31077 Toulouse, France
[2] Univ Toulouse, UPS, INPT, LCC, F-31077 Toulouse, France
[3] Univ Zurich, Dept Biochem, CH-8057 Zurich, Switzerland
来源：
METALLOMICS | 2010年 / 2卷 / 11期
基金：
瑞士国家科学基金会;
关键词：
GROWTH-INHIBITORY FACTOR; METALLOTHIONEIN-III; SYNAPTIC ZINC; METAL; ROLES;
D O I：
10.1039/c0mt00027b
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The reactive oxygen species H2O2 promotes the Zn-7-metallothionein-3 induced A beta(40) aggregation of fibrillar type structures via slow cysteine oxidation and Zn2+ release, whereas amorphous aggregates are formed by addition of Zn2+ to A beta(40).
引用
收藏
页码：741 / 744
页数：4
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