ELECTROCHEMICAL AND THEORETICAL EVALUATION OF THE INTERACTION BETWEEN DNA AND AMODIAQUINE. EVIDENCE OF THE GUANINE ADDUCT FORMATION

被引：8
|
作者：
Arguelho, Maria Lara P. M. [1 ]
Alves, Jose do Patrocinio H. [1 ]
Stradiotto, Nelson R. [2 ]
Lacerda Junior, Valdemar [3 ]
Pires, Jose Maria [3 ]
Beatriz, Adilson [4 ]
机构：
[1] Univ Fed Sergipe, Dept Quim, BR-49100000 Sao Cristovao, SE, Brazil
[2] Univ Estadual Paulista, Inst Quim, BR-14801970 Araraquara, SP, Brazil
[3] Univ Fed Espirito Santo, Dept Quim, BR-29075910 Vitoria, ES, Brazil
[4] Univ Fed Mato Grosso do Sul, Dept Quim, BR-79070900 Campo Grande, MS, Brazil
来源：
QUIMICA NOVA | 2010年 / 33卷 / 06期
基金：
巴西圣保罗研究基金会;
关键词：
amodiaquine; guanine; adduct; UNCOMPLICATED MALARIA; PLASMODIUM-FALCIPARUM; IN-VITRO; CHLOROQUINE; DAMAGE; 1,10-PHENANTHROLINE; OXIDATION; CHILDREN; EFFICACY; ORIGIN;
D O I：
10.1590/S0100-40422010000600014
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The electrochemical behavior of the interaction of-amodiaquine with DNA on a carbon paste electrode was studied using voltametric techniques. In an acid medium, an electroactive adduct is formed when amodiaquine interacts with DNA. The anodic peak is dependent on pH, scan rate and the concentration of the pharmaceutical. Adduct formation is irreversible in nature, and preferentially occurs by interaction of the amodiaquine with the guanine group. Theoretical calculations for optimization of geometry, and DFT analyses and on the electrostatic potential map (EPM), were used in-the investigation of adduct formation between amodiaquine and DNA.
引用
收藏
页码：1291 / 1296
页数：6
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