ELECTROCHEMICAL AND THEORETICAL EVALUATION OF THE INTERACTION BETWEEN DNA AND AMODIAQUINE. EVIDENCE OF THE GUANINE ADDUCT FORMATION

被引：8

作者：

Arguelho, Maria Lara P. M. ^{[1
]}

Alves, Jose do Patrocinio H. ^{[1
]}

Stradiotto, Nelson R. ^{[2
]}

Lacerda Junior, Valdemar ^{[3
]}

Pires, Jose Maria ^{[3
]}

Beatriz, Adilson ^{[4
]}

机构：

[1] Univ Fed Sergipe, Dept Quim, BR-49100000 Sao Cristovao, SE, Brazil

[2] Univ Estadual Paulista, Inst Quim, BR-14801970 Araraquara, SP, Brazil

[3] Univ Fed Espirito Santo, Dept Quim, BR-29075910 Vitoria, ES, Brazil

[4] Univ Fed Mato Grosso do Sul, Dept Quim, BR-79070900 Campo Grande, MS, Brazil

来源：

QUIMICA NOVA | 2010年 / 33卷 / 06期

基金：

巴西圣保罗研究基金会;

关键词：

amodiaquine; guanine; adduct; UNCOMPLICATED MALARIA; PLASMODIUM-FALCIPARUM; IN-VITRO; CHLOROQUINE; DAMAGE; 1,10-PHENANTHROLINE; OXIDATION; CHILDREN; EFFICACY; ORIGIN;

D O I：

10.1590/S0100-40422010000600014

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The electrochemical behavior of the interaction of-amodiaquine with DNA on a carbon paste electrode was studied using voltametric techniques. In an acid medium, an electroactive adduct is formed when amodiaquine interacts with DNA. The anodic peak is dependent on pH, scan rate and the concentration of the pharmaceutical. Adduct formation is irreversible in nature, and preferentially occurs by interaction of the amodiaquine with the guanine group. Theoretical calculations for optimization of geometry, and DFT analyses and on the electrostatic potential map (EPM), were used in-the investigation of adduct formation between amodiaquine and DNA.

引用

页码：1291 / 1296

页数：6

共 50 条

[1] Electrochemical and theoretical study on interaction between erlotinib and DNA
Jovanovic, Milan
Nikolic, Katarina
Carapic, Marija
Aleksic, Mara M.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2023, 234
[2] Electrochemical, spectroscopic, and theoretical studies on the interaction between azathioprine and DNA
Jalali, Fahimeh
Rasaee, Gelareh
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2015, 81 : 427 - 434
[3] Theoretical Investigation on Interaction between Guanine and Luteolin
Li, Lai-cai
Bai, Kun-kun
Cai, Wan-fei
CHINESE JOURNAL OF CHEMICAL PHYSICS, 2013, 26 (05) : 533 - 540
[4] Interactions between DNA purinic bases and amodiaquine: A theoretical approach
Lacerda Junior, Valdemar
Pires, Jose Maria
Beatriz, Adilson
Arguelho, Maria Lara P. M.
ORBITAL-THE ELECTRONIC JOURNAL OF CHEMISTRY, 2010, 2 (01): : 1 - 10
[5] Electrochemical biosensor for the detection of interaction between arsenic trioxide and DNA based on guanine signal
Ozsoz, M
Erdem, A
Kara, P
Kerman, K
Ozkan, D
ELECTROANALYSIS, 2003, 15 (07) : 613 - 619
[6] RAPID TECHNIQUE FOR EVALUATION OF DNA ADDUCT FORMATION
JACKSON, MA
KING, LC
BALL, LM
LEWTAS, J
MEDICAL AND PEDIATRIC ONCOLOGY, 1983, 11 (01): : 68 - 68
[7] RELATIONSHIPS BETWEEN DNA ADDUCT FORMATION AND CARCINOGENESIS
SWENBERG, JA
RICHARDSON, FC
BOUCHERON, JA
DYROFF, MC
ENVIRONMENTAL HEALTH PERSPECTIVES, 1985, 62 (OCT) : 177 - 183
[8] DNA adduct formation from interaction with pesticides in plants
Andrade, Todd C.
Boerth, Donald W.
Eder, Erwin
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2007, 233 : 816 - 816
[9] Disposable electrochemical biosensor for the detection of the interaction between DNA and lycorine based on guanine and adenine signals
Karadeniz, H
Gulmez, B
Sahinci, F
Erdem, A
Kaya, GI
Unver, N
Kivcak, B
Ozsoz, M
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2003, 33 (02) : 295 - 302
[10] DNA adduct formation by ochratoxin A: Review of the available evidence
Mally, A
Dekant, W
FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT, 2005, 22 : 65 - 74

← 1 2 3 4 5 →