Methanolic extract of African mistletoe (Viscum album) improves carbohydrate metabolism and hyperlipidemia in streptozotocin-induced diabetic rats

被引：35

作者：

Adaramoye, Oluwatosin ^{[1
,5
]}

Amanlou, Massoud ^{[2
]}

Habibi-Rezaei, Mehran ^{[3
]}

Pasalar, Parvin ^{[4
]}

Moosavi-Movahedi, Ali ^{[5
]}

机构：

[1] Univ Ibadan, Dept Biochem, Coll Med, Ibadan, Nigeria

[2] Univ Tehran, Tehran Univ Med Sci, Fac Pharm, Dept Med Chem, Tehran 14174, Iran

[3] Univ Tehran, Coll Sci, Sch Biol, Tehran 14174, Iran

[4] Univ Tehran Med Sci, Fac Med, Dept Clin Biochem, Tehran, Iran

[5] Univ Tehran, IBB, Tehran 14174, Iran

来源：

ASIAN PACIFIC JOURNAL OF TROPICAL MEDICINE | 2012年 / 5卷 / 06期

基金：

美国国家科学基金会;

关键词：

Hypoglycemic; African mistletoe; Diabetes; Streptozotocin; COLORIMETRIC METHOD; SERUM; ANTIOXIDANTS; TOXICITY; SEEDS;

D O I：

10.1016/S1995-7645(12)60073-X

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Objective: To justify the use of African mistletoe (AM) Viscum album (V. album) in folkoric medicine to treat diabetes. Methods: In one experiment, the fasting blood glucose (FBG) levels of diabetic rats were monitored for 4 h. Diabetic rats were treated with AM at doses of 50 mg/kg (AM1) and 100 mg/kg (AM2), glibenclamide (GB) (positive control) and saline solution (SS). In another experiment, diabetic rats were treated with AM2, GB and SS daily for 3 weeks. Results: AM1 and AM2 elicited significant (P<0.05) hypoglycaemic effects within 4 h of extract administration. AM1 and AM2 decreased the FBG by 41% and 49%, respectively, at 2 h. AM2 was found to lower FBG by 51%, relative to baseline, which was comparable to GB at 3 h. In the second experiment, AM2 and GB significantly (P<0.05) decreased the FBG by 34% and 51%, respectively. This was followed by marked decrease in levels of HbA1C in AM2- and GB- treated diabetic rats. AM2 significantly (P<0.05) decreased the STZ-induced increase in levels of serum triglyceride, urea, lactate dehydrogenase, alpha -amylase and low-density lipoprotein-cholesterol. Furthermore, diabetic rats treated with AM2 had significantly (P<0.05) elevated high-density lipoprotein-cholesterol. In contrast, STZ administration produced insignificant (P<0.05) effect on the levels of serum creatinine and total bilirubin. Conclusions: Extract of African mistletoe has anti-diabetic and anti-hyperlipidemic effects in STZ-diabetic rats. AM may find clinical application in the amelioration of diabetes-induced lipid disorders.

引用

页码：427 / 433

页数：7

共 41 条

[1] Hypoglycaemic and hypolipidaemic effects of fractions from kolaviron, a biflavonoid complex from Garcinia Kola in streptozotocin-induced diabetes mellitus rats [J].