An apolipoprotein influencing triglycerides in humans and mice revealed by comparative sequencing

被引：768

作者：

Pennacchio, LA

Olivier, M

Hubacek, JA

Cohen, JC

Cox, DR

Fruchart, JC

Krauss, RM

Rubin, EM ^{[1
]}

机构：

[1] Univ Calif Berkeley, Lawrence Berkeley Lab, Genome Sci Dept, Berkeley, CA 94720 USA

[2] Stanford Univ, Sch Med, Dept Genet, Stanford Human Genome Ctr, Palo Alto, CA 94304 USA

[3] Univ Texas, SW Med Ctr, Ctr Human Nutr, Dallas, TX 75390 USA

[4] Univ Texas, SW Med Ctr, McDermott Ctr Human Growth & Dev, Dallas, TX 75390 USA

[5] Inst Pasteur, Dept Atherosclerosis, INSERM, U545, F-59019 Lille, France

[6] Univ Lille, Fac Pharm, F-59006 Lille, France

来源：

SCIENCE | 2001年 / 294卷 / 5540期

关键词：

D O I：

10.1126/science.1064852

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Comparison of genomic DNA sequences from human and mouse revealed a new apolipoprotein (APO) gene (APOAV) located proximal to the well-characterized APOAI/CIII/AIV gene cluster on human 11q23. Mice expressing a human APOAV transgene showed a decrease in plasma triglyceride concentrations to one-third of those in control mice; conversely, knockout mice lacking Apoav had four times as much plasma triglycerides as controls. In humans, single nucleotide polymorphisms (SNPs) across the APOAV locus were found to be significantly associated with plasma triglyceride levels in two independent studies. These findings indicate that APOAV is an important determinant of plasma triglyceride levels, a major risk factor for coronary artery disease.

引用

页码：169 / 173

页数：5

共 43 条

[1]

ALLAIN CC, 1974, CLIN CHEM, V20, P470

[2]

Allan CM, 1996, J LIPID RES, V37, P1510

[3] Families with familial combined hyperlipidemia and families enriched for coronary artery disease share genetic determinants for the atherogenic lipoprotein phenotype [J].