Long-term exposure to extremely low-frequency magnetic fields impairs spatial recognition memory in mice

被引：31

作者：

Fu, Yu ^{[2
,3
]}

Wang, Cangkai ^{[4
]}

Wang, Jianhong ^{[2
]}

Lei, Yanlin ^{[2
]}

Ma, Yuanye ^{[1
,2
]}

机构：

[1] Chinese Acad Sci, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mech, Lab Primate Neurosci Res, Kunming 650233, Yunnan, Peoples R China

[2] Chinese Acad Sci, Kunming Primate Res Ctr, Kunming 650233, Yunnan, Peoples R China

[3] Chinese Acad Sci, Grad Univ, Beijing, Peoples R China

[4] Xiamen Univ, Coll Med, Dept Pharmacol, Xiamen, Fujian, Peoples R China

来源：

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY | 2008年 / 35卷 / 07期

关键词：

electromagnetic field; extremely low-frequency; mice; spatial recognition memory; Y-maze;

D O I：

10.1111/j.1440-1681.2008.04922.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. In the present study, we investigated the short- and long-term effects of extremely low-frequency (ELF) magnetic fields on spatial recognition memory in mice by using a two-trial recognition Y-maze that is based on the innate tendency of rodents to explore novel environments. 2. Mice were exposed to 25 or 50 Hz electromagnetic fields for either 7 (short term) or 25 days (long term) and then tested in the Y-maze. 3. The results indicated that neither short- nor long-term exposure to magnetic fields affected the locomotor activity of mice in the Y-maze. However, long-term exposure to 50 Hz fields reduced recognition of the novel arm. 4. Our findings suggest that ELF magnetic fields impair spatial recognition memory in the Y-maze depending on the field strength and/or duration of exposure.

引用

页码：797 / 800

页数：4

共 31 条

[1] The synthetic enantiomer of pregnenolone sulfate is very active on memory in rats and mice, even more so than its physiological neurosteroid counterpart: Distinct mechanisms? [J].