Ste20-related kinases: effectors of signaling and morphogenesis in fungi

被引：44
作者：
Boyce, Kylie J. [1 ]
Andrianopoulos, Alex [1 ]
机构：
[1] Univ Melbourne, Dept Genet, Melbourne, Vic 3010, Australia
来源：
TRENDS IN MICROBIOLOGY | 2011年 / 19卷 / 08期
关键词：
YEAST SACCHAROMYCES-CEREVISIAE; P21-ACTIVATED PROTEIN-KINASE; MITOGEN-ACTIVATED PROTEIN; HIGH-TEMPERATURE GROWTH; FISSION YEAST; USTILAGO-MAYDIS; SCHIZOSACCHAROMYCES-POMBE; CRYPTOCOCCUS-NEOFORMANS; CELL POLARITY; CANDIDA-ALBICANS;
D O I：
10.1016/j.tim.2011.04.006
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The family of Ste20-related kinases is conserved from yeast to mammals and includes the p21 activated kinases (PAKs) and germinal centre kinases (GCKs). These kinases have been shown to be involved in signaling through mitogen activated protein kinase (MAPK) pathways and in morphogenesis through the regulation of cytokinesis and actin-dependent polarized growth. This review concentrates on the role of Ste20-related kinases in fungi where recent research has revealed roles for both PAKs and GCKs in the regulation of cytokinesis and in previously unidentified roles in promoting hyphal growth and differentiation of asexual development structures. In particular, the importance of PAKs during pathogenesis will be examined.
引用
收藏
页码：400 / 410
页数：11
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