Response of Toll-like receptors in experimental Guillain-Barre syndrome: A kinetic analysis

被引：15

作者：

Gries, Manuela ^{[1
]}

Davies, Laura ^{[1
]}

Liu, Yang ^{[1
]}

Bachhuber, Armin ^{[1
]}

Spiegel, Joerg ^{[1
]}

Dillmann, Ulrich ^{[1
]}

Hartmann, Tobias ^{[1
,2
]}

Fassbender, Klaus ^{[1
,2
]}

Walter, Silke ^{[1
]}

机构：

[1] Univ Saarland, Dept Neurol, D-66421 Homburg, Germany

[2] Univ Saarland, German Inst Dementia Prevent DIDP, D-66421 Homburg, Germany

来源：

NEUROSCIENCE LETTERS | 2012年 / 518卷 / 02期

关键词：

Experimental autoimmune neuritis; Toll-like receptors; Guillain-Barre syndrome; EXPERIMENTAL AUTOIMMUNE NEURITIS; PERIPHERAL NERVOUS-SYSTEM; MACROPHAGES; CELLS;

D O I：

10.1016/j.neulet.2012.04.077

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Guillain-Barre syndrome (GBS) is an autoimmune disorder caused by the interaction between cellular and humoral immune responses in the peripheral nervous system. Toll-like receptors (TLRs) are key players in innate and have regulatory functions in adaptive immunity. In this study, we systematically examined expression patterns of TLRs in sciatic nerve and lymphoid organs during the disease course of murine experimental autoimmune neuritis and in blood from Guillain-Barre patients. A kinetic response pattern was identified, characterized by a pronounced up-regulation of TLR2, 6 and 11 on T cells and TLR4 and 6 on APCs, while TLR1 expression was decreased. Moreover, an enhanced expression of the disease promoting cytokine Interleukin-(IL)17A was detected. Additional analysis of GBS patients revealed an up-regulation of TLR2, TLR4 and TLR6 mRNA, negatively correlated with disease severity. This first systematic analysis of TLR expression pattern may contribute to elucidating the role of TLRs in GBS pathophysiology. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

引用

页码：154 / 160

页数：7

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