Association of Dietary Acid Load with the Prevalence of Metabolic Syndrome among Participants in Baseline Survey of the Japan Multi-Institutional Collaborative Cohort Study

被引：23

作者：

Arisawa, Kokichi ^{[1
]}

Katsuura-Kamano, Sakurako ^{[1
]}

Uemura, Hirokazu ^{[1
]}

Nguyen Van Tien ^{[1
]}

Hishida, Asahi ^{[2
]}

Tamura, Takashi ^{[2
]}

Kubo, Yoko ^{[2
]}

Tsukamoto, Mineko ^{[2
]}

Tanaka, Keitaro ^{[3
]}

Hara, Megumi ^{[3
]}

Takezaki, Toshiro ^{[4
]}

Nishimoto, Daisaku ^{[5
]}

Koyama, Teruhide ^{[6
]}

Ozaki, Etsuko ^{[6
]}

Suzuki, Sadao ^{[7
]}

Nishiyama, Takeshi ^{[7
]}

Kuriki, Kiyonori ^{[8
]}

Kadota, Aya ^{[9
]}

Takashima, Naoyuki ^{[9
,10
]}

Ikezaki, Hiroaki ^{[11
,12
]}

Murata, Masayuki ^{[12
]}

Oze, Isao ^{[13
]}

Matsuo, Keitaro ^{[13
,14
]}

Mikami, Haruo ^{[15
]}

Nakamura, Yohko ^{[15
]}

Takeuchi, Kenji ^{[2
]}

Wakai, Kenji ^{[2
]}

机构：

[1] Tokushima Univ, Dept Prevent Med, Grad Sch Biomed Sci, Tokushima 7708503, Japan

[2] Nagoya Univ, Dept Prevent Med, Grad Sch Med, Nagoya, Aichi 4668550, Japan

[3] Saga Univ, Fac Med, Dept Prevent Med, Saga 8498501, Japan

[4] Kagoshima Univ, Dept Int Isl & Community Med, Grad Sch Med & Dent Sci, Kagoshima 8908544, Japan

[5] Kagoshima Univ, Fac Med, Sch Hlth Sci, Kagoshima 8908544, Japan

[6] Kyoto Prefectural Univ Med, Dept Epidemiol Community Hlth & Med, Kyoto 6028566, Japan

[7] Nagoya City Univ, Dept Publ Hlth, Grad Sch Med Sci, Nagoya, Aichi 4678601, Japan

[8] Univ Shizuoka, Sch Food & Nutr Sci, Div Nutr Sci, Lab Publ Hlth, Shizuoka 4228526, Japan

[9] Shiga Univ Med Sci, Dept Publ Hlth, Otsu, Shiga 5202192, Japan

[10] Kindai Univ, Fac Med, Dept Publ Hlth, Osaka 5898511, Japan

[11] Kyushu Univ, Fac Med Sci, Dept Comprehens Gen Internal Med, Grad Sch Med, Fukuoka 8128582, Japan

[12] Kyushu Univ Hosp, Dept Gen Internal Med, Fukuoka 8128582, Japan

[13] Aichi Canc Ctr Res Inst, Div Canc Epidemiol & Prevent, Nagoya, Aichi 4648681, Japan

[14] Nagoya Univ, Dept Canc Epidemiol, Grad Sch Med, Nagoya, Aichi 4668550, Japan

[15] Chiba Canc Ctr Res Inst, Canc Prevent Ctr, Chiba 2608717, Japan

来源：

NUTRIENTS | 2020年 / 12卷 / 06期

关键词：

dietary acid load; metabolic syndrome; net endogenous acid production; cross-sectional study; FOOD FREQUENCY QUESTIONNAIRE; NATIONAL-HEALTH; FURUKAWA NUTRITION; INSULIN-RESISTANCE; BLOOD-PRESSURE; ANION GAP; RISK; PROTEIN; HYPERTENSION; MAGNESIUM;

D O I：

10.3390/nu12061605

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

The association between dietary acid load and metabolic syndrome (MetS) has not been fully investigated. A cross-sectional study was performed on 14,042 men and 14,105 women (aged 35-69 years) who participated in a baseline survey of the Japan Multi-Institutional Collaborative Cohort study. Dietary acid load was assessed using the net-endogenous-acid-production (NEAP) score that is closely correlated with the rate of renal net acid excretion. MetS was diagnosed according to the Joint Interim Statement Criteria of 2009 using body-mass index instead of waist circumference. After adjusting for potential confounders, higher NEAP scores were associated with a significantly increased odds ratio (OR) of MetS, obesity, high blood pressure, and high fasting blood glucose. These associations remained significant after further adjustment for carbohydrate intake or two nutrient-pattern scores significantly associated with MetS. After adjustment for fiber, iron, potassium, and vitamin pattern scores, the OR of MetS for the highest quartile of NEAP scores, relative to the lowest quartile, was 1.25 (95% confidence interval 1.12-1.39). There was no significant interaction between sex, age, or body-mass index and NEAP. Higher dietary acid load was associated with a higher prevalence of MetS and several of its components, independently of carbohydrate intake or nutrient patterns.

引用

页数：11

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