Preserved SARS-CoV-2 Vaccine Cell-Mediated Immunogenicity in Patients With Inflammatory Bowel Disease on Immune-Modulating Therapies

被引：10

作者：

Boland, Brigid S. ^{[1
]}

Goodwin, Benjamin ^{[2
]}

Zhang, Zeli ^{[2
]}

Bloom, Nathaniel ^{[2
]}

Kato, Yu ^{[2
]}

Neill, Jennifer ^{[1
]}

Le, Helen ^{[1
]}

Tysl, Tiffani ^{[1
]}

Collins, Angelina E. ^{[1
]}

Dulai, Parambir S. ^{[1
]}

Singh, Siddharth ^{[1
]}

Nguyen, Nghia H. ^{[1
]}

Grifoni, Alba ^{[2
]}

Sette, Alessandro ^{[2
,3
]}

Weiskopf, Daniela ^{[2
]}

Chang, John T. ^{[1
]}

Dan, Jennifer M. ^{[2
,3
]}

机构：

[1] Univ Calif San Diego, Div Gastroenterol, La Jolla, CA 92093 USA

[2] La Jolla Inst Immunol, Ctr Infect Dis & Vaccine Res, La Jolla, CA USA

[3] Univ Calif San Diego, Dept Med, Div Infect Dis & Global Publ Hlth, La Jolla, CA 92093 USA

来源：

CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY | 2022年 / 13卷 / 04期

关键词：

D O I：

10.14309/ctg.0000000000000484

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Immune-modulating medications for inflammatory bowel diseases (IBDs) have been associated with suboptimal vaccine responses. There are conflicting data with SARS-CoV-2 vaccination. We therefore assessed SARS-CoV-2 vaccine immunogenicity at 2 weeks after second mRNA vaccination in 29 patients with IBD compared with 12 normal healthy donors. We observed reduced humoral immunity in patients with IBD on infliximab. However, we observed no difference in humoral and cell-mediated immunity in patients with IBD on infliximab with a thiopurine or vedolizumab compared with normal healthy donors. This is the first study to demonstrate comparable cell-mediated immunity with SARS-CoV-2 vaccination in patients with IBD treated with different immune-modulating medications.

引用

页数：5

共 15 条

[1] Immunogenicity of High Dose Influenza Vaccine for Patients with Inflammatory Bowel Disease on Anti-TNF Monotherapy: A Randomized Clinical Trial [J].

Caldera, Freddy ;

Hillman, Luke ;

Saha, Sumona ;

Wald, Arnold ;

Grimes, Ian ;

Zhang, Youqi ;

Sharpe, Abigail R. ;

Reichelderfer, Mark ;

Hayney, Mary S. .

INFLAMMATORY BOWEL DISEASES, 2020, 26 (04) :593-602

[2] T Follicular Helper Cell Biology: A Decade of Discovery and Diseases [J].

Crotty, Shane .

IMMUNITY, 2019, 50 (05) :1132-1148

[3] Immunological memory to SARS-CoV-2 assessed for up to 8 months after infection [J].

Dan, Jennifer M. ;

Mateus, Jose ;

Kato, Yu ;

Hastie, Kathryn M. ;

Yu, Esther Dawen ;

Faliti, Caterina E. ;

Grifoni, Alba ;

Ramirez, Sydney, I ;

Haupt, Sonya ;

Frazier, April ;

Nakao, Catherine ;

Rayaprolu, Vamseedhar ;

Rawlings, Stephen A. ;

Peters, Bjoern ;

Krammer, Florian ;

Simon, Viviana ;

Saphire, Erica Ollmann ;

Smith, Davey M. ;

Weiskopf, Daniela ;

Sette, Alessandro ;

Crotty, Shane .

SCIENCE, 2021, 371 (6529) :587-+

[4] Ustekinumab Inhibits T Follicular Helper Cell Differentiation in Patients With Crohn's Disease [J].

Globig, Anna-Maria ;

Sommer, Nikola Patricia ;

Wild, Katharina ;

Schardey, Josefine ;

Zoldan, Katharina ;

Thomann, Anne Kerstin ;

Schulte, Lucas-Alexander ;

Schreiner, Rupert ;

Reindl, Wolfgang ;

Klaus, Jochen ;

Schempp, Christoph Mathis ;

Hofmann, Maike ;

Thimme, Robert ;

Boettler, Tobias ;

Hasselblatt, Peter .

CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY, 2021, 11 (01) :1-12

[5] Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals [J].

Grifoni, Alba ;

Weiskopf, Daniela ;

Ramirez, Sydney, I ;

Mateus, Jose ;

Dan, Jennifer M. ;

Moderbacher, Carolyn Rydyznski ;

Rawlings, Stephen A. ;

Sutherland, Aaron ;

Premkumar, Lakshmanane ;

Jadi, Ramesh S. ;

Marrama, Daniel ;

de Silva, Aravinda M. ;

Frazier, April ;

Carlin, Aaron F. ;

Greenbaum, Jason A. ;

Peters, Bjoern ;

Krammer, Florian ;

Smith, Davey M. ;

Crotty, Shane ;

Sette, Alessandro .

CELL, 2020, 181 (07) :1489-+

[6]

Harrington JE., 2020, CROHNS COLITIS 360, V2, potaa082, DOI DOI 10.1093/crocol/otaa082

[7] Humoral Immune Response to Messenger RNA COVID-19 Vaccines Among Patients With Inflammatory Bowel Disease [J].

Kappelman, Michael D. ;

Weaver, Kimberly N. ;

Boccieri, Margie ;

Firestine, Ann ;

Zhang, Xian ;

Long, Millie D. .

GASTROENTEROLOGY, 2021, 161 (04) :1340-+

[8] Infliximab is associated with attenuated immunogenicity to BNT162b2 and ChAdOx1 nCoV-19 SARS-CoV-2 vaccines in patients with IBD [J].

Kennedy, Nicholas A. ;

Lin, Simeng ;

Goodhand, James R. ;

Chanchlani, Neil ;

Hamilton, Benjamin ;

Bewshea, Claire ;

Nice, Rachel ;

Chee, Desmond ;

Cummings, J. R. Fraser ;

Fraser, Aileen ;

Irving, Peter M. ;

Kamperidis, Nikolaos ;

Kok, Klaartje B. ;

Lamb, Christopher Andrew ;

Macdonald, Jonathan ;

Mehta, Shameer ;

Pollok, Richard C. G. ;

Raine, Tim ;

Smith, Philip J. ;

Verma, Ajay Mark ;

Jochum, Simon ;

McDonald, Timothy J. ;

Sebastian, Shaji ;

Lees, Charlie W. ;

Powell, Nick ;

Ahmad, Tariq .

GUT, 2021, 70 (10) :1884-1893

[9]

Lee AS., 2020, CROHNS COLITIS 360, V2, potaa086

[10] Immunosuppression Impairs Response to Pneumococcal Polysaccharide Vaccination in Patients With Inflammatory Bowel Disease [J].

Melmed, Gil Y. ;

Agarwal, Nik ;

Frenck, Robert W. ;

Ippoliti, Andrew F. ;

Ibanez, Patricio ;

Papadakis, Konstantinos A. ;

Simpson, Peter ;

Barolet-Garcia, Cristina ;

Ward, Joel ;

Targan, Stephan R. ;

Vasiliauskas, Eric A. .

AMERICAN JOURNAL OF GASTROENTEROLOGY, 2010, 105 (01) :148-154

← 1 2 →