Development of 5-Fluorouracil Derivatives as Anticancer Agents

被引：54

作者：

Pan, Xiaoyan ^{[1
]}

Wang, Chen ^{[1
]}

Wang, Fang ^{[1
]}

Li, Pengfei ^{[1
]}

Hu, Zhigang ^{[1
]}

Shan, Yuanyuan ^{[2
]}

Zhang, Jie ^{[1
]}

机构：

[1] Xi An Jiao Tong Univ, Sch Med, Xian 710061, Shaanxi Provinc, Peoples R China

[2] Xi An Jiao Tong Univ, Coll Med, Affiliated Hosp 1, Dept Pharm, Xian 710061, Shaanxi Provinc, Peoples R China

来源：

CURRENT MEDICINAL CHEMISTRY | 2011年 / 18卷 / 29期

关键词：

5-Fluorouracil (5-FU); anticancer; thymidylate synthase; antimetabolite; toxicity; BREAST-CANCER CELLS; ANTITUMOR-ACTIVITY; BIOLOGICAL EVALUATION; NATURAL-PRODUCTS; PRODRUGS; RELEASE; CYTOTOXICITY; ANALOGS; MICE; NUCLEOSIDES;

D O I：

10.2174/092986711797287584

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

5-Fluorouracil (5-FU) is one of the most potent antimetabolites which have been widely used in the treatment of advanced solid tumors. As an anticancer agent, because of its low efficacy and high toxicity, numerous modifications of 5-FU structure have been performed. A great number of novel 5-FU derivatives have been developed with highly efficient and much less toxic. In this paper, the recent development of novel 5-FU derivatives as potent antitumor agents is reviewed and discussed.

引用

页码：4538 / 4556

页数：19

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