Neolignans and amide alkaloids from the stems of Piper kadsura and their neuroprotective activity

被引：17

作者：

Chen, Hui ^{[1
,2
,3
,4
]}

Zhu, Ying ^{[1
]}

Zhang, Ya-Lun ^{[1
]}

Zeng, Meng-Nan ^{[1
,2
,3
]}

Cao, Yan-Gang ^{[1
]}

Sun, Pan-Ting ^{[1
]}

Cao, Bing ^{[1
]}

Du, Kun ^{[1
]}

Zhao, Xuan ^{[1
]}

Wang, Xiao-Wei ^{[4
]}

Zheng, Xiao-Ke ^{[1
,2
,3
]}

Feng, Wei-Sheng ^{[1
,2
,3
]}

机构：

[1] Henan Univ Chinese Med, Sch Pharm, Zhengzhou 450046, Peoples R China

[2] Coconstruct Collaborat Innovat Ctr Chinese Med & R, Zhengzhou 450046, Peoples R China

[3] Educ Minist PR China, Zhengzhou 450046, Peoples R China

[4] NMPA Key Lab Qual Control Tradit Chinese Med Chine, Zhengzhou 450018, Peoples R China

来源：

PHYTOCHEMISTRY | 2022年 / 203卷

关键词：

Piper kadsura (Choisy) ohwi; Piperaceae; Neolignans; Amide alkaloids; Neuroprotective activity; Autophagy; LIGNANS;

D O I：

10.1016/j.phytochem.2022.113336

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Four undescribed neolignans and three undescribed amide alkaloids, along with twelve known compounds, were isolated from the stems of Piper kadsura (Choisy) Ohwi. The structures of the new compounds were determined by spectroscopic analysis, quantum-chemical calculations, and Mo-2(OAc)(4)-induced ECD analysis. The neuro-protective effects of these compounds against A beta(25-35)-induced cell damage in PC12 cells were investigated, and eight compounds exhibited significant neuroprotective effects against A beta(25-35)-induced PC12 cell damage, with the EC50 values of 3.06-29.3 mu M. Three of these compounds were selected for further experiments, and they appear to reduce apoptosis and enhance autophagy against A beta(25-35)-induced PC12 cell damage.

引用

页数：9

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