Matrix Metalloproteinases: How Much Can They Do?

被引：29

作者：

Agren, Magnus S. ^{[1
,2
,3
]}

auf dem Keller, Ulrich ^{[4
]}

机构：

[1] Univ Copenhagen, Bispebjerg Hosp, Digest Dis Ctr, DK-2400 Copenhagen, Denmark

[2] Univ Copenhagen, Bispebjerg Hosp, Copenhagen Wound Healing Ctr, DK-2400 Copenhagen, Denmark

[3] Univ Copenhagen, Fac Hlth & Med Sci, Dept Clin Med, DK-2400 Copenhagen, Denmark

[4] Tech Univ Denmark, Dept Biotechnol & Biomed, DK-2800 Lyngby, Denmark

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2020年 / 21卷 / 08期

关键词：

extracellular matrix; inflammation; wound healing; cytokines; proteinases; interstitial collagens; MYOFIBROBLAST FORMATION; KERATINOCYTE MIGRATION; ANASTOMOTIC LEAKAGE; BREAKING STRENGTH; I COLLAGEN; INHIBITION; DEGRADATION; DOXYCYCLINE; MMP-10; SKIN;

D O I：

10.3390/ijms21082678

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Zinc-dependent matrix metalloproteinases (MMPs) belong to metzincins that comprise not only 23 human MMPs but also other metalloproteinases, such as 21 human ADAMs (a disintegrin and metalloproteinase domain) and 19 secreted ADAMTSs (a disintegrin and metalloproteinase thrombospondin domain). The many setbacks from the clinical trials of broad-spectrum MMP inhibitors for cancer indications in the late 1990s emphasized the extreme complexity of the participation of these proteolytic enzymes in biology. This editorial mini-review summarizes the Special Issue, which includes four review articles and 10 original articles that highlight the versatile roles of MMPs, ADAMs, and ADAMTSs, in normal physiology as well as in neoplastic and destructive processes in tissue. In addition, we briefly discuss the unambiguous involvement of MMPs in wound healing.

引用

页数：9

共 53 条

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