Tuft Cells Are Present in Submandibular Glands Across Species

被引：5

作者：

dos Santos, Harim Tavares ^{[1
,3
]}

Nam, Kihoon ^{[1
,3
]}

Maslow, Frank M. ^{[1
,3
]}

Small, Travis ^{[1
,3
]}

Galloway, Tabitha L., I ^{[1
]}

Dooley, Laura M. ^{[1
]}

Tassone, Patrick T. ^{[1
]}

Zitsch, Robert P. ^{[1
]}

Weisman, Gary A. ^{[2
,3
]}

Baker, Olga J. ^{[1
,2
,3
]}

机构：

[1] Univ Missouri, Dept Otolaryngol Head & Neck Surg, Columbia, MO 65211 USA

[2] Univ Missouri, Dept Biochem, Columbia, MO 65211 USA

[3] Univ Missouri, Christopher S Bond Life Sci Ctr, Columbia, MO 65211 USA

来源：

JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY | 2022年 / 70卷 / 09期

基金：

美国国家卫生研究院;

关键词：

chemosensation; immunology; secretion; taste receptors; CHEMOSENSORY CELLS; INTESTINAL TUFT; RECEPTORS; IMMUNITY; BITTER;

D O I：

10.1369/00221554221120301

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Tuft cells are bottle-shaped, microvilli-projecting chemosensory cells located in the lining of a variety of epithelial tissues and, following their identification approximately 60 years ago, have been linked to immune system function in a variety of epithelia. Until recently, Tuft cells had not been convincingly demonstrated to be present in salivary glands with their detection by transmission electron microscopy only shown in a handful of earlier studies using rat salivary glands, and no follow-up work has been conducted to verify their presence in salivary glands of other species. Here, we demonstrate that Tuft cells are present in the submandibular glands of various species (i.e., mouse, pig and human) using transmission electron microscopy and confocal immunofluorescent analysis for the POU class 2 homeobox 3 (POU2F3), which is considered to be a master regulator of Tuft cell identity.

引用

页码：659 / 667

页数：9

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