Brain cannabinoid systems as targets for the therapy of neurological disorders

被引:102
作者
Consroe, P [1 ]
机构
[1] Univ Arizona, Hlth Sci Ctr, Dept Pharmacol & Toxicol, Tucson, AZ 85721 USA
关键词
cannabis; cannabinoids; cannabinoid receptor; marijuana; neurological disorders;
D O I
10.1006/nbdi.1998.0220
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Unprecedented developments in cannabinoid research within the past decade include discovery of a brain (CB1) and peripheral (CB2) receptor; endogenous ligands, anandamide, and 2-arachidonylglycerol; cannabinoid drug-induced partial and inverse agonism at CB1 receptors, antagonism of NMDA receptors and glutamate, and antioxidant activity; and preferential CB1 receptor localization in areas subserving spasticity, pain, abnormal involuntary movements, seizures, and amnesia. These endogenous structures and chemicals and mechanisms are potentially new pathophysiologic substrates, and targets for novel cannabinoid treatments, of several neurological disorders, (C) 1998 Academic Press.
引用
收藏
页码:534 / 551
页数:18
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