One-Step Homogeneous DNA Assay with Single-Nanoparticle Detection

被引：91

作者：

Han, Guojun ^{[1
]}

Xing, Zhi ^{[1
]}

Dong, Yanhua ^{[1
]}

Zhang, Sichun ^{[1
]}

Zhang, Xinrong ^{[1
]}

机构：

[1] Tsinghua Univ, Dept Chem, Key Lab Atom & Mol Nanosci, Educ Minist, Beijing 100084, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 15期

基金：

中国国家自然科学基金; 国家高技术研究发展计划(863计划);

关键词：

aggregation; DNA; gold; mass spectrometry; nanoparticles; PLASMA-MASS SPECTROMETRY; RESONANCE ENERGY-TRANSFER; GOLD NANOPARTICLES; SCATTERING TECHNIQUE; MOLECULAR BEACONS; LIGHT-SCATTERING; HYBRIDIZATION; IMMUNOASSAY; PROBES; DIFFERENTIATION;

D O I：

10.1002/anie.201006838

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Staying single: A DNA hybridization assay employs gold-nanoparticle (AuNP) probes and single-particle inductively coupled plasma spectrometry (ICP-MS; see picture). The degree of aggregation of AuNPs is characterized by simultaneous measurement of decreased concentrations of the AuNP population and increased individual sizes. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

收藏

页码：3462 / 3465

页数：4

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