Serotonin transporter knockout rats show improved strategy set-shifting and reduced latent inhibition

被引：32
作者：
Nonkes, Lourens J. P. [1 ]
van de Vondervoort, Ilse I. G. M. [1 ]
de Leeuw, Mark J. C. [1 ]
Wijlaars, Linda P. [1 ]
Maes, Joseph H. R. [2 ]
Homberg, Judith R. [1 ]
机构：
[1] Radboud Univ Nijmegen, Med Ctr, Dept Cognit Neurosci, Donders Inst Brain Cognit & Behav,Ctr Neurosci, NL-6525 EZ Nijmegen, Netherlands
[2] Radboud Univ Nijmegen, Dept Biol Psychol, Donders Inst BrainCognit & Behav, Ctr Cognit, NL-6525 HR Nijmegen, Netherlands
来源：
LEARNING & MEMORY | 2012年 / 19卷 / 05期
关键词：
MEDIAL PREFRONTAL CORTEX; BEHAVIORAL FLEXIBILITY; ORBITOFRONTAL CORTEX; GENETIC-VARIATION; 5-HTTLPR POLYMORPHISM; ATTENTIONAL SET; HUMAN AMYGDALA; INACTIVATION; DEPRESSION; MORPHOLOGY;
D O I：
10.1101/lm.025908.112
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Behavioral flexibility is a cognitive process depending on prefrontal areas allowing adaptive responses to environmental changes. Serotonin transporter knockout (5-HTT-/-) rodents show improved reversal learning in addition to orbitofrontal cortex changes. Another form of behavioral flexibility, extradimensional strategy set-shifting (EDSS), heavily depends on the medial prefrontal cortex. This region shows functional changes in 5-HTT-/- rodents as well. Here we subjected 5-HTT-/- rats and their wild-type counterparts to an EDSS paradigm and a supplementary latent inhibition task. Results indicate that 5-HTT-/- rats also show improved EDSS, and indicate that reduced latent inhibition may contribute as an underlying mechanism.
引用
收藏
页码：190 / 193
页数：4
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