Serotonin transporter knockout rats show improved strategy set-shifting and reduced latent inhibition

被引：32

作者：

Nonkes, Lourens J. P. ^{[1
]}

van de Vondervoort, Ilse I. G. M. ^{[1
]}

de Leeuw, Mark J. C. ^{[1
]}

Wijlaars, Linda P. ^{[1
]}

Maes, Joseph H. R. ^{[2
]}

Homberg, Judith R. ^{[1
]}

机构：

[1] Radboud Univ Nijmegen, Med Ctr, Dept Cognit Neurosci, Donders Inst Brain Cognit & Behav,Ctr Neurosci, NL-6525 EZ Nijmegen, Netherlands

[2] Radboud Univ Nijmegen, Dept Biol Psychol, Donders Inst BrainCognit & Behav, Ctr Cognit, NL-6525 HR Nijmegen, Netherlands

来源：

LEARNING & MEMORY | 2012年 / 19卷 / 05期

关键词：

MEDIAL PREFRONTAL CORTEX; BEHAVIORAL FLEXIBILITY; ORBITOFRONTAL CORTEX; GENETIC-VARIATION; 5-HTTLPR POLYMORPHISM; ATTENTIONAL SET; HUMAN AMYGDALA; INACTIVATION; DEPRESSION; MORPHOLOGY;

D O I：

10.1101/lm.025908.112

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Behavioral flexibility is a cognitive process depending on prefrontal areas allowing adaptive responses to environmental changes. Serotonin transporter knockout (5-HTT-/-) rodents show improved reversal learning in addition to orbitofrontal cortex changes. Another form of behavioral flexibility, extradimensional strategy set-shifting (EDSS), heavily depends on the medial prefrontal cortex. This region shows functional changes in 5-HTT-/- rodents as well. Here we subjected 5-HTT-/- rats and their wild-type counterparts to an EDSS paradigm and a supplementary latent inhibition task. Results indicate that 5-HTT-/- rats also show improved EDSS, and indicate that reduced latent inhibition may contribute as an underlying mechanism.

引用

页码：190 / 193

页数：4

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