Simultaneous Administration of 2-Aminoethyl Diphenylborinate and Chloroquine Reverses Chloroquine Resistance in Malaria Parasites

被引：5

作者：

Mossaad, Ehab ^{[1
,2
,3
]}

Furuyama, Wakako ^{[1
]}

Enomoto, Masahiro ^{[4
]}

Kawai, Satoru ^{[5
]}

Mikoshiba, Katsuhiko ^{[6
]}

Kawazu, Shin-ichiro ^{[1
]}

机构：

[1] Obihiro Univ Agr & Vet Med, Natl Res Ctr Protozoan Dis, Obihiro, Hokkaido, Japan

[2] Gifu Univ, United Grad Sch Vet Sci, Gifu, Japan

[3] Sudan Univ Sci & Technol, Coll Vet Med, Khartoum, Sudan

[4] Princess Margaret Canc Ctr, Toronto, ON, Canada

[5] Dokkyo Med Univ, Lab Trop Med & Parasitol, Mibu, Tochigi, Japan

[6] RIKEN, Brain Sci Inst, Dev Neurobiol Lab, Saitama, Japan

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2015年 / 59卷 / 05期

关键词：

PLASMODIUM-FALCIPARUM; SECRETION; INVASION; RECEPTOR;

D O I：

10.1128/AAC.04805-14

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A nearly complete reversal of chloroquine (CQ) resistance in the CQ-resistant Plasmodium falciparum K-1 strain, with a significant decrease in the mean +/- standard deviation (SD) 50% inhibitory concentration (IC50) from 1,050 +/- 95 nM to 14 +/- 2 nM, was achieved in vitro by the simultaneous administration of 2-aminoethyl diphenylborinate (2-APB). The CQ resistance-reversing activity of 2-APB, which showed the same efficacy as verapamil, was also observed in an in vivo mouse infection model with the CQ-resistant Plasmodium chabaudi AS(30CQ) strain.

引用

页码：2890 / 2892

页数：3

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