PAR4 (Protease-Activated Receptor 4) PARticularly Important 4 Antiplatelet Therapy

被引:25
作者
Han, Xu [1 ]
Nieman, Marvin T. [1 ]
机构
[1] Case Western Reserve Univ, Dept Pharmacol, 10900 Euclid Ave, Cleveland, OH 44106 USA
基金
美国国家卫生研究院;
关键词
THROMBIN-RECEPTOR; SECONDARY PREVENTION; VORAPAXAR; INHIBITION; ANTAGONIST;
D O I
10.1161/ATVBAHA.117.310550
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
[No abstract available]
引用
收藏
页码:287 / 289
页数:3
相关论文
共 19 条
[1]   Overview of the 2014 Food and Drug Administration Cardiovascular and Renal Drugs Advisory Committee Meeting About Vorapaxar [J].
Baker, Nevin C. ;
Lipinski, Michael J. ;
Lhermusier, Thibault ;
Waksman, Ron .
CIRCULATION, 2014, 130 (15) :1287-1294
[2]   Pepducin-based intervention of thrombin-receptor signaling and systemic platelet activation [J].
Covic, L ;
Misra, M ;
Badar, J ;
Singh, C ;
Kuliopulos, A .
NATURE MEDICINE, 2002, 8 (10) :1161-1165
[3]   Inhibition of protease-activated receptor 4 impairs platelet procoagulant activity during thrombus formation in human blood [J].
French, S. L. ;
Arthur, J. F. ;
Lee, H. ;
Nesbitt, W. S. ;
Andrews, R. K. ;
Gardiner, E. E. ;
Hamilton, J. R. .
JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2016, 14 (08) :1642-1654
[4]   Protease-activated receptor-4 uses dual prolines and an anionic retention motif for thrombin recognition and cleavage [J].
Jacques, SL ;
Kuliopulos, A .
BIOCHEMICAL JOURNAL, 2003, 376 (03) :733-740
[5]   Substrate-assisted catalysis of the PAR1 thrombin receptor - Enhancement of macromolecular association and cleavage [J].
Jacques, SL ;
LeMasurier, M ;
Sheridan, PJ ;
Seeley, SK ;
Kuliopulos, A .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (52) :40671-40678
[6]   Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin [J].
Kahn, ML ;
Nakanishi-Matsui, M ;
Shapiro, MJ ;
Ishihara, H ;
Coughlin, SR .
JOURNAL OF CLINICAL INVESTIGATION, 1999, 103 (06) :879-887
[7]   Vorapaxar in the Secondary Prevention of Atherothrombotic Events [J].
Morrow, David A. ;
Braunwald, Eugene ;
Bonaca, Marc P. ;
Ameriso, Sebastian F. ;
Dalby, Anthony J. ;
Fish, Mary Polly ;
Fox, Keith A. A. ;
Lipka, Leslie J. ;
Liu, Xuan ;
Nicolau, Jose Carlos ;
Ophuis, A. J. Oude ;
Paolasso, Ernesto ;
Scirica, Benjamin M. ;
Spinar, Jindrich ;
Theroux, Pierre ;
Wiviott, Stephen D. ;
Strony, John ;
Murphy, Sabina A. .
NEW ENGLAND JOURNAL OF MEDICINE, 2012, 366 (15) :1404-1413
[8]   Targeting the anionic region of human protease-activated receptor 4 inhibits platelet aggregation and thrombosis without interfering with hemostasis [J].
Mumaw, M. M. ;
De La Fuente, M. ;
Noble, D. N. ;
Nieman, M. T. .
JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2014, 12 (08) :1331-1341
[9]   Interaction of thrombin with PAR1 and PAR4 at the thrombin cleavage site [J].
Nieman, Marvin T. ;
Schmaier, Alvin H. .
BIOCHEMISTRY, 2007, 46 (29) :8603-8610
[10]   Vorapaxar for secondary prevention of thrombotic events for patients with previous myocardial infarction: a prespecified subgroup analysis of the TRA 2°P-TIMI 50 trial [J].
Scirica, Benjamin M. ;
Bonaca, Marc P. ;
Braunwald, Eugene ;
De Ferrari, Gaetano M. ;
Isaza, Daniel ;
Lewis, Basil S. ;
Mehrhof, Felix ;
Merlini, Piera A. ;
Murphy, Sabina A. ;
Sabatine, Marc S. ;
Tendera, Michal ;
Van de Werf, Frans ;
Wilcox, Robert ;
Morrow, David A. .
LANCET, 2012, 380 (9850) :1317-1324