Human Endometrial Organoids: Recent Research Progress and Potential Applications

被引：11

作者：

Lou, Liqun ^{[1
,2
]}

Kong, Shuangbo ^{[2
]}

Sun, Yunyan ^{[3
]}

Zhang, Zhenbo ^{[1
,4
]}

Wang, Haibin ^{[2
]}

机构：

[1] Shanghai Jiao Tong Univ, Shanghai Gen Hosp, Reprod Med Ctr, Dept Obstet & Gynecol, Shanghai, Peoples R China

[2] Xiamen Univ, Fujian Prov Key Lab Reprod Hlth Res, Dept Obstet & Gynecol, Affiliated Hosp 1,Sch Med, Xiamen, Peoples R China

[3] Shanghai Jiao Tong Univ, Xinhua Hosp, Dept Obstet & Gynecol, Shanghai, Peoples R China

[4] Shanghai Jiao Tong Univ, Renji Hosp, Shanghai Key Lab Assisted Reprod & Reprod Genet, Shanghai, Peoples R China

来源：

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2022年 / 10卷

基金：

中国国家自然科学基金;

关键词：

human endometrial organoids; genetic manipulation; coculture model; drug screening; epithelium; TO-MESENCHYMAL TRANSITION; EXTRACELLULAR-MATRIX; OVARIAN-CANCER; GROWTH-FACTOR; LONG-TERM; CELLS; WNT; WOMEN; SENSITIVITY; EXPRESSION;

D O I：

10.3389/fcell.2022.844623

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Since traditional two-dimensional (2D) cell culture cannot meet the demand of simulating physiological conditions in vivo, three-dimensional (3D) culture systems have been developed. To date, most of these systems have been applied for the culture of gastrointestinal and neural tissue. As for the female reproductive system, the culture of endometrial and oviductal tissues in Matrigel has also been performed, but there are still some problems that remain unsolved. This review highlights recent progress regarding endometrial organoids, focusing on the signal for organoid derivation and maintenance, the coculture of the epithelium and stroma, the drug screening using organoids from cancer patients, and provides a potential guideline for genome editing in endometrial organoids.

引用

页数：7

共 78 条

[1] Tissue stiffness at the human maternal-fetal interface [J].

Abbas, Yassen ;

Carnicer-Lombarte, Alejandro ;

Gardner, Lucy ;

Thomas, Jake ;

Brosens, Jan J. ;

Moffett, Ashley ;

Sharkey, Andrew M. ;

Franze, Kristian ;

Burton, Graham J. ;

Oyen, Michelle L. .

HUMAN REPRODUCTION, 2019, 34 (10) :1999-2008

[2] Comparative evaluation of NOTCH signaling molecules in the endometrium of women with various gynecological diseases during the window of implantation [J].

Amjadi, Fatemehsadat ;

Salehi, Ensieh ;

Zandieh, Zahra ;

Rashidi, Mandana ;

Taleahmad, Sara ;

Masrour, Mojgan Javedani ;

Aflatoonian, Reza ;

Mehdizadeh, Mehdi .

IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 2019, 22 (04) :426-431

[3]

APLIN JD, 1988, CELL TISSUE RES, V253, P231

[4] Fast and efficient generation of knock-in human organoids using homology-independent CRISPR-Cas9 precision genome editing [J].

Artegiani, Benedetta ;

Hendriks, Delilah ;

Beumer, Joep ;

Kok, Rutger ;

Zheng, Xuan ;

Joore, Indi ;

Chuva de Sousa Lopes, Susana ;

van Zon, Jeroen ;

Tans, Sander ;

Clevers, Hans .

NATURE CELL BIOLOGY, 2020, 22 (03) :321-+

[5] Tumor necrosis factor-α stimulates the epithelial-to-mesenchymal transition of human colonic organoids [J].

Bates, RC ;

Mercurio, AM .

MOLECULAR BIOLOGY OF THE CELL, 2003, 14 (05) :1790-1800

[6] A microenvironment-inspired synthetic three-dimensional model for pancreatic ductal adenocarcinoma organoids [J].

Below, Christopher R. ;

Kelly, Joanna ;

Brown, Alexander ;

Humphries, Jonathan D. ;

Hutton, Colin ;

Xu, Jingshu ;

Lee, Brian Y. ;

Cintas, Celia ;

Zhang, Xiaohong ;

Hernandez-Gordillo, Victor ;

Stockdale, Linda ;

Goldsworthy, Matthew A. ;

Geraghty, Joe ;

Foster, Lucy ;

O'Reilly, Derek A. ;

Schedding, Barbara ;

Askari, Janet ;

Burns, Jessica ;

Hodson, Nigel ;

Smith, Duncan L. ;

Lally, Catherine ;

Ashton, Garry ;

Knight, David ;

Mironov, Aleksandr ;

Banyard, Antonia ;

Eble, Johannes A. ;

Morton, Jennifer P. ;

Humphries, Martin J. ;

Griffith, Linda G. ;

Jorgensen, Claus .

NATURE MATERIALS, 2022, 21 (01) :110-+

[7] Patient-derived organoids from endometrial disease capture clinical heterogeneity and are amenable to drug screening [J].

Boretto, Matteo ;

Maenhoudt, Nina ;

Luo, Xinlong ;

Hennes, Aurelie ;

Boeckx, Bram ;

Bui, Bich ;

Heremans, Ruben ;

Perneell, Lisa ;

Kobayashi, Hiroto ;

Van Zundert, Indra ;

Brems, Hilde ;

Cox, Benoit ;

Ferrante, Marc ;

Uji-i, Hiroshi ;

Koh, Kian Peng ;

D'Hooghe, Thomas ;

Vanhie, Arne ;

Vergote, Ignace ;

Meuleman, Christel ;

Tomassetti, Carla ;

Lambrechts, Diether ;

Vriens, Joris ;

Timmerman, Dirk ;

Vankelecom, Hugo .

NATURE CELL BIOLOGY, 2019, 21 (08) :1041-+

[8] Development of organoids from mouse and human endometrium showing endometrial epithelium physiology and long-term expandability [J].

Boretto, Matteo ;

Cox, Benoit ;

Noben, Manuel ;

Hendriks, Nikolai ;

Fassbender, Amelie ;

Roose, Heleen ;

Amant, Frederic ;

Timmerman, Dirk ;

Tomassetti, Carla ;

Vanhie, Arne ;

Meuleman, Christel ;

Ferrante, Marc ;

Vankelecom, Hugo .

DEVELOPMENT, 2017, 144 (10) :1775-1786

[9] R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/β-catenin signaling [J].

Carmon, Kendra S. ;

Gong, Xing ;

Lin, Qiushi ;

Thomas, Anthony ;

Liu, Qingyun .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (28) :11452-11457

[10] Fibroblast growth factor-10: A stromal mediator of epithelial function in the ovine uterus [J].

Chen, C ;

Spencer, TE ;

Bazer, FW .

BIOLOGY OF REPRODUCTION, 2000, 63 (03) :959-966

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