Detection of Molluscum Contagiosum Virus (MCV) DNA in the Plasma of an Immunocompromised Patient and Possible Reduction of MCV DNA With CMX-001

被引：14

作者：

Cohen, Jeffrey I. ^{[1
]}

Davila, Wilmer ^{[1
]}

Ali, Mir A. ^{[1
]}

Turk, Siu-Ping ^{[2
]}

Cowen, Edward W. ^{[3
]}

Freeman, Alexandra F. ^{[4
]}

Wang, Kening ^{[1
]}

机构：

[1] NIAID, Med Virol Sect, Infect Dis Lab, Bethesda, MD 20892 USA

[2] NIAID, Clin Studies Unit, Lab Clin Infect Dis, Bethesda, MD 20892 USA

[3] NCI, Dermatol Branch, Ctr Canc Res, Bethesda, MD 20892 USA

[4] NIAID, Immunopathogenesis Sect, Lab Clin Infect Dis, NIH, Bethesda, MD 20892 USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2012年 / 205卷 / 05期

关键词：

IMMUNODEFICIENCY; IDENTIFICATION; VACCINIA;

D O I：

10.1093/infdis/jir853

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Molluscum contagiosum virus (MCV) is a poxvirus that causes localized papules in healthy persons. We evaluated a woman with severe immunodeficiency and disseminated MCV. During treatment with CMX-001, an antiviral with activity against other poxviruses, MCV DNA was detected in 20% of plasma samples. When the patient was not receiving CMX-001, MCV DNA was detected in 50% of samples. We also noted improvement in warts on her fingers during CMX-001 therapy. Although MCV is caused by direct inoculation of virus into skin in healthy persons, in a severely immunocompromised person MCV DNA was present in blood and may spread by viremia.

引用

页码：794 / 797

页数：4

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