Polarization-sensitive optical coherence tomography-based imaging, parameterization, and quantification of human cartilage degeneration

被引：23

作者：

Brill, Nicolai ^{[1
]}

Wirtz, Mathias ^{[1
]}

Merhof, Dorit ^{[2
]}

Tingart, Markus ^{[3
]}

Jahr, Holger ^{[3
]}

Truhn, Daniel ^{[4
]}

Schmitt, Robert ^{[1
,5
]}

Nebelung, Sven ^{[4
]}

机构：

[1] Fraunhofer Inst Prod Technol, Steinbachstr 17, D-52074 Aachen, Germany

[2] Rhein Westfal TH Aachen, Inst Imaging & Comp Vis, Kopernikusstr 16, D-52074 Aachen, Germany

[3] Aachen Univ Hosp, Dept Orthopaed Surg, Pauwelsstr 30, D-52074 Aachen, Germany

[4] Aachen Univ Hosp, Dept Diagnost & Intervent Radiol, Pauwelsstr 30, D-52074 Aachen, Germany

[5] Rhein Westfal TH Aachen, Lab Machine Tools & Prod Engn, Manfred Weck Haus,Steinbachstr 19, D-52074 Aachen, Germany

来源：

JOURNAL OF BIOMEDICAL OPTICS | 2016年 / 21卷 / 07期

关键词：

optical diagnostics for medicine; optical coherence tomography; polarization-sensitive optical coherence tomography; cartilage; imaging; ARTICULAR-CARTILAGE; OSTEOARTHRITIC CARTILAGE; COLLAGEN STRUCTURE; BIREFRINGENCE; ORIENTATION; INTEGRITY; ARTHRITIS; NETWORK; DISEASE; FIBERS;

D O I：

10.1117/1.JBO.21.7.076013

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Polarization-sensitive optical coherence tomography (PS-OCT) is a light-based, high-resolution, real-time, noninvasive, and nondestructive imaging modality yielding quasimicroscopic cross-sectional images of cartilage. As yet, comprehensive parameterization and quantification of birefringence and tissue properties have not been performed on human cartilage. PS-OCT and algorithm-based image analysis were used to objectively grade human cartilage degeneration in terms of surface irregularity, tissue homogeneity, signal attenuation, as well as birefringence coefficient and band width, height, depth, and number. Degeneration-dependent changes were noted for the former three parameters exclusively, thereby questioning the diagnostic value of PS-OCT in the assessment of human cartilage degeneration. (C) 2016 Society of Photo-Optical Instrumentation Engineers (SPIE)

引用

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