The Role of Breast Cancer Stem Cells in Metastasis and Therapeutic Implications

被引：144

作者：

Velasco-Velazquez, Marco A. ^{[1
,3
]}

Popov, Vladimir M. ^{[1
]}

Lisanti, Michael P. ^{[2
]}

Pestell, Richard G. ^{[1
]}

机构：

[1] Thomas Jefferson Univ, Dept Canc Biol, Kimmel Canc Ctr, Philadelphia, PA 19107 USA

[2] Thomas Jefferson Univ, Dept Stem Cell Biol & Regenerat Med, Kimmel Canc Ctr, Philadelphia, PA 19107 USA

[3] Univ Nacl Autonoma Mexico, Fac Med, Dept Pharmacol, Mexico City 04510, DF, Mexico

来源：

AMERICAN JOURNAL OF PATHOLOGY | 2011年 / 179卷 / 01期

关键词：

FATE DETERMINATION FACTOR; EPITHELIAL-MESENCHYMAL TRANSITION; CIRCULATING TUMOR-CELLS; IN-VITRO PROPAGATION; ALDEHYDE DEHYDROGENASE; MAMMARY TUMORIGENESIS; CHEMOKINE RECEPTORS; CELLULAR INVASION; INITIATING CELLS; DRUG-RESISTANCE;

D O I：

10.1016/j.ajpath.2011.03.005

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Cancer stem cells (CSCs) possess the capacity to self-renew and to generate heterogeneous lineages of cancer cells that comprise tumors. A substantial body of evidence supports a model in which CSCs play a major role in the initiation, maintenance, and clinical outcome of cancers. In contrast, analysis of the role of CSCs in metastasis has been mainly conceptual and speculative. This review summarizes recent data that support the theory of CSCs as the source of metastatic lesions in breast cancer, with a focus on the key role of the microenvironment in the sternness-metastasis link. (Am J Pathol 2011, 179:2-11; DOI: 10.1016/j.ajpath.2011.03.005)

引用

页码：2 / 11

页数：10

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