Polybrominated diphenyl ether (PBDE) and poly- and perfluoroalkyl substance (PFAS) exposures during pregnancy and maternal depression

被引：32

作者：

Vuong, Ann M. ^{[1
,2
]}

Yolton, Kimberly ^{[3
]}

Braun, Joseph M. ^{[4
]}

Sjodin, Andreas ^{[5
]}

Calafat, Antonia M. ^{[5
]}

Xu, Yingying ^{[3
]}

Dietrich, Kim N. ^{[2
]}

Lanphear, Bruce P. ^{[6
,7
]}

Chen, Aimin ^{[2
,8
]}

机构：

[1] Univ Nevada, Dept Environm & Occupat Hlth, Las Vegas Sch Publ Hlth, 4700 S Maryland Pkwy,Suite 335,MS 3063, Las Vegas, NV 89119 USA

[2] Univ Cincinnati, Dept Environm Hlth, Div Epidemiol, Coll Med, POB 670056, Cincinnati, OH 45267 USA

[3] Univ Cincinnati, Cincinnati Childrens Hosp Med Ctr, Dept Pediat, Div Gen & Community Pediat,Coll Med, 3333 Burnet Ave,MLC 7035, Cincinnati, OH 45229 USA

[4] Brown Univ, Dept Epidemiol, Sch Publ Hlth, 121 South Main St,Box G-S121-2, Providence, RI 02912 USA

[5] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Div Lab Sci, Atlanta, GA 30341 USA

[6] Simon Fraser Univ, BC Childrens Hosp, Res Inst, 8888 Univ Dr, Burnaby, BC V5A 1S6, Canada

[7] Simon Fraser Univ, Fac Hlth Sci, 8888 Univ Dr, Burnaby, BC V5A 1S6, Canada

[8] Univ Penn, Perelman Sch Med, Dept Biostat Epidemiol & Informat, 423 Guardian Dr,Blockley Hall 231, Philadelphia, PA 19104 USA

来源：

ENVIRONMENT INTERNATIONAL | 2020年 / 139卷

关键词：

Polybrominated diphenyl ethers (PBDEs); Poly; and perfluoroalkyl substances (PFAS); Depression; Maternal; Pregnancy; Women; BROMINATED FLAME RETARDANTS; POLYCHLORINATED-BIPHENYLS PCBS; POLYUNSATURATED FATTY-ACIDS; THYROID-HORMONE; OCCUPATIONAL-EXPOSURE; PERFLUOROOCTANE SULFONATE; COGNITIVE-DEVELOPMENT; PERINATAL DEPRESSION; POSTNATAL DEPRESSION; DISORDERS PRIOR;

D O I：

10.1016/j.envint.2020.105694

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Background: Experimental studies in rodents suggest that polybrominated diphenyl ethers (PBDEs) and poly- and perfluoroalkyl substances (PFAS) may contribute to depressive symptoms. Few studies have examined the impact of these chemicals on depression in adults. Objective: To examine the associations between serum PBDE and PFAS concentrations during pregnancy and repeated measures of depressive symptoms in women assessed from pregnancy to 8 years postpartum. Methods: This study was based on 377 women from the Health Outcomes and Measures of the Environment Study, a birth cohort in Cincinnati, OH (USA). PBDEs (BDE-28, -47, -99, -100, -153, and SPBDEs) and PFAS (perfluorooctanoate [PFOA], perfluorooctane sulfonate [PFOS], perfluorohexane sulfonate [PFHxS], perfluorononanoate [PFNA]) were quantified in maternal serum at 16 +/- 3 weeks gestation. Depressive symptoms were measured using the Beck Depression Inventory-II (BDI-II) at similar to 20 weeks gestation and up to seven times during postpartum visits (4 weeks, 1, 2, 3, 4, 5, and 8 years). We used linear mixed models to estimate covariate-adjusted associations between chemical concentrations and repeated measures of BDI-II. Multinomial logistic regression models were used to estimate the relative risk ratios of having a medium or high depression trajectory. Results: We found that a 10-fold increase in BDE-28 at 16 +/- 3 weeks gestation was associated with significantly increased BDI-II scores (beta = 2.5 points, 95% confidence interval [CI] 0.8, 4.2) from pregnancy to 8 years postpartum. Significant positive associations were also observed with BDE-47, -100, -153, and SPBDEs. A 10-fold increase in SPBDEs was associated with a 4.6-fold increased risk (95% CI 1.8, 11.8) of a high trajectory for BDI-II compared to a low trajectory. We observed no significant associations between PFAS and BDI-II scores. Conclusion: PBDEs during pregnancy were associated with more depressive symptoms among women in this cohort.

引用

页数：9

共 103 条

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