Latent effects of prenatal malnutrition on adult health - The example of schizophrenia

被引:60
作者
Susser, Ezra [1 ,2 ]
Clair, David St. [3 ]
He, Lin [4 ,5 ]
机构
[1] Columbia Univ, Mailman Sch Publ Hlth, Dept Epidemiol, New York, NY 10032 USA
[2] New York State Psychiat Inst & Hosp, New York, NY 10032 USA
[3] Univ Aberdeen, Dept Mental Hlth, Aberdeen, Scotland
[4] Shanghai Inst Biol Sci, Inst Nutr Sci, Shanghai, Peoples R China
[5] Shanghai Jiao Tong Univ, Shanghai 200030, Peoples R China
来源
REDUCING THE IMPACT OF POVERTY ON HEALTH AND HUMAN DEVELOPMENT: SCIENTIFIC APPROACHES | 2008年 / 1136卷
关键词
fetal malnutrition; schizophrenia; famine;
D O I
10.1196/annals.1425.024
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
It is well established that malnutrition in children has adverse effects on development. Only recently, however, has it become possible to examine the full scope of adverse effects of malnutrition across the life course, which would include latent effects of fetal or childhood malnutrition on health and disease in adult life. We review here a series of studies which have linked early prenatal famine to the risk of schizophrenia in the offspring. Thus we aim to draw attention to the need to look beyond the concurrent effects of malnutrition and consider also the effects that may become apparent decades later.
引用
收藏
页码:185 / 192
页数:8
相关论文
共 49 条
[1]  
Almond D., 2007, 13384 NAT BUR EC RES
[2]  
[Anonymous], 1991, Lancet, V338, P131, DOI 10.1016/0140-6736(91)90133-A
[3]  
[Anonymous], 2001, The world health report-mental health: New understanding, new hope
[4]   Stress-induced variation in evolution: from behavioural plasticity to genetic assimilation [J].
Badyaev, AV .
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 2005, 272 (1566) :877-886
[5]  
Barker DJ., 1998, Mothers, babies, and health in later life, V2
[6]  
Becker Jasper., 1998, Hungry Ghosts: Mao's Secret Famine
[7]   Folic acid deficiency increases chromosomal instability, chromosome 21 aneuploidy and sensitivity to radiation-induced micronuclei [J].
Beetstra, S ;
Thomas, P ;
Salisbury, C ;
Turner, J ;
Fenech, M .
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 2005, 578 (1-2) :317-326
[8]   Belated concerns and latent effects -: The example of schizophrenia [J].
Bresnahan, Michaeline ;
Susser, Ezra .
EPIDEMIOLOGY, 2007, 18 (05) :583-584
[9]   Further evidence of relation between prenatal famine and major affective disorder [J].
Brown, AS ;
van Os, J ;
Driessens, C ;
Hoek, HW ;
Susser, ES .
AMERICAN JOURNAL OF PSYCHIATRY, 2000, 157 (02) :190-195
[10]  
BROWN AS, 2008, SCHIZOPHR B IN PRESS