Examining allostatic load, neighborhood socioeconomic status, symptom burden and mortality in multiple myeloma patients

被引：15

作者：

Obeng-Gyasi, Samilia ^{[1
]}

Graham, Noah ^{[2
]}

Kumar, Shaji ^{[3
]}

Lee, Ju-Whei ^{[2
]}

Jacobus, Susanna ^{[2
]}

Weiss, Matthias ^{[4
]}

Cella, David ^{[5
]}

Zhao, Fengmin ^{[2
]}

Ip, Edward H. ^{[6
]}

O'Connell, Nathaniel ^{[2
]}

Hong, Fangxin ^{[2
]}

Peipert, Devin J. ^{[7
]}

Gareen, IIana. F. ^{[8
,9
]}

Timsina, Lava R. ^{[10
]}

Gray, Robert ^{[2
]}

Wagner, Lynne I. ^{[6
]}

Carlos, Ruth C. ^{[11
]}

机构：

[1] Ohio State Univ, Columbus, OH 43210 USA

[2] Dana Farber Canc Inst, ECOG ACRIN Biostat Ctr, Boston, MA 02115 USA

[3] Mayo Clin, Rochester, MN USA

[4] ThedaCare Canc Care, Appleton, WI USA

[5] Northwestern Univ, Robert H Lurie Comprehens Canc Ctr, Chicago, IL 60611 USA

[6] Wake Forest Univ, Bowman Gray Sch Med, Winston Salem, NC USA

[7] Northwestern Univ, Feinberg Sch Med, Chicago, IL 60611 USA

[8] Brown Univ, Dept Epidemiol, Providence, RI 02912 USA

[9] Brown Univ, Ctr Stat Sci, Providence, RI 02912 USA

[10] Indiana Univ Sch Med, Indianapolis, IN 46202 USA

[11] Univ Michigan, Comprehens Canc Ctr, Ann Arbor, MI 48109 USA

来源：

BLOOD CANCER JOURNAL | 2022年 / 12卷 / 04期

基金：

美国国家卫生研究院;

关键词：

BODY-MASS INDEX; HEALTH CONSEQUENCES; SURVIVAL; IMPACT; DISPARITIES; ADAPTATION; STRESS; INCOME; LEVEL; LINKS;

D O I：

10.1038/s41408-022-00648-y

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The objective of this study is to examine the association between neighborhood socioeconomic status (nSES) and baseline allostatic load (AL) and clinical trial endpoints in patients enrolled in the E1A11 therapeutic trial in multiple myeloma (MM). Study endpoints were symptom burden (pain, fatigue, and bother) at baseline and 5.5 months, non-completion of induction therapy, overall survival (OS) and progression-free survival (PFS). Multivariable logistic and Cox regression examined associations between nSES, AL and patient outcomes. A 1-unit increase in baseline AL was associated with greater odds of high fatigue at baseline (adjusted OR [95% CI] = 1.21 [1.08-1.36]) and a worse OS (adjusted hazard ratio, [95% CI] = 1.21 [1.06-1.37]). High nSES was associated with worse baseline bother (middle OR = 4.22 [1.11-16.09] and high 4.49 [1.16-17.43]) compared to low nSES. There was no association between AL or nSES and symptom burden at 5.5 months, non-completion of induction therapy or PFS. Additionally, there was no association between nSES and OS. AL may have utility as a predictive marker for OS among patients with MM and may allow individualization of treatment. Future studies should standardize and validate AL patients with MM.

引用

页数：8

共 51 条

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