Response to vaccination against different types of antigens in patients with chronic lymphocytic leukaemia

被引：61
作者：
Sinisalo, M
Aittoniemi, J
Oivanen, P
Käyhty, H
Ölander, RM
Vilpo, J
机构：
[1] Tampere Univ Hosp, Dept Internal Med, FIN-33521 Tampere, Finland
[2] Tampere Univ Hosp, Dept Clin Microbiol, Ctr Lab Med, FIN-33521 Tampere, Finland
[3] Natl Publ Hlth Inst, Helsinki, Finland
[4] Tampere Univ Hosp, Ctr Lab Med, Dept Clin Chem, Lab Mol Haematol, Tampere, Finland
[5] Univ Tampere, Sch Med, Tampere, Finland
来源：
BRITISH JOURNAL OF HAEMATOLOGY | 2001年 / 114卷 / 01期
关键词：
CLL; Haemophilus influenzae; Streptococcus pneumoniae; vaccination; antibody response;
D O I：
10.1046/j.1365-2141.2001.02882.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
We investigated responses to vaccination against pneumococcal polysaccharide, Haemophilus influenzae b (Hib) conjugate and tetanus toxoid antigens in 31 patients with chronic lymphocytic leukaemia (CLL) and 25 controls. While in the control group all antibody responses against different antigens were highly significant, in the patient group clear evidence for responsiveness was detected only in the case of Hib polysaccharide antigen. Certain CLL patient subgroups showed low reactivity against tetanus toxoid antigen. In conclusion, plain polysaccharide vaccines seem to be ineffective in patients with CLL. Conjugate vaccines, in turn, are immunogenic and may offer protection against infections caused by encapsulated bacteria in these patients. Further studies concerning an optimal vaccination scheme and clinical efficiency are warranted.
引用
收藏
页码：107 / 110
页数：4
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