Adhesive L1CAM-Robo Signaling Aligns Growth Cone F-Actin Dynamics to Promote Axon-Dendrite Fasciculation in C-elegans

被引：19

作者：

Chen, Chun-Hao ^{[1
,2
]}

Hsu, Hao-Wei ^{[1
]}

Chang, Yun-Hsuan ^{[1
]}

Pan, Chun-Liang ^{[1
]}

机构：

[1] Natl Taiwan Univ, Inst Mol Med, Coll Med, 7 Chung Shan South Rd, Taipei 10002, Taiwan

[2] CALTECH, Div Biol & Bioengn, Pasadena, CA 91125 USA

来源：

DEVELOPMENTAL CELL | 2019年 / 48卷 / 02期

关键词：

CUES; CELL; MAINTENANCE; GUIDANCE; HOMOLOG; SAX-7; GENES;

D O I：

10.1016/j.devcel.2018.10.028

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Neurite fasciculation through contact-dependent signaling is important for the wiring and function of the neuronal circuits. Here, we describe a type of axon-dendrite fasciculation in C. elegans, where proximal dendrites of the nociceptor PVD adhere to the axon of the ALA interneuron. This axon-dendrite fasciculation is mediated by a previously uncharacterized adhesive signaling by the ALA membrane signal SAX-7/L1CAM and the PVD receptor SAX-3/Robo but independent of Slit. L1CAM physically interacts with Robo and instructs dendrite adhesion in a Robo-dependent manner. Fasciculation mediated by L1CAM-Robo signaling aligns F-actin dynamics in the dendrite growth cone and facilitates dynamic growth cone behaviors for efficient dendrite guidance. Disruption of PVD dendrite fasciculation impairs nociceptive mechanosensation and rhythmicity in body curvature, suggesting that dendrite fasciculation governs the functions of mechanosensory circuits. Our work elucidates the molecular mechanisms by which adhesive axon-dendrite signaling shapes the construction and function of sensory neuronal circuits.

引用

页码：215 / +

页数：19

共 40 条

[1] C-elegans multi-dendritic sensory neurons: Morphology and function [J].

Albeg, Adi ;

Smith, Cody J. ;

Chatzigeorgiou, Marios ;

Feitelson, Dror G. ;

Hall, David H. ;

Schafer, William R. ;

Miller, David M., III ;

Treinin, Millet .

MOLECULAR AND CELLULAR NEUROSCIENCE, 2011, 46 (01) :308-317

[2] Axon fasciculation and differences in midline kinetics between pioneer and follower axons within commissural fascicles [J].

Bak, M ;

Fraser, SE .

DEVELOPMENT, 2003, 130 (20) :4999-5008

[3] A molecular clutch between the actin flow and N-cadherin adhesions drives growth cone migration [J].

Bard, Lucie ;

Boscher, Cecile ;

Lambert, Mireille ;

Mege, Rene-Marc ;

Choquet, Daniel ;

Thoumine, Olivier .

JOURNAL OF NEUROSCIENCE, 2008, 28 (23) :5879-5890

[4] Post-guidance signaling by extracellular matrix-associated Slit/Slit-N maintains fasciculation and position of axon tracts in the nerve cord [J].

Bhat, Krishna Moorthi .

PLOS GENETICS, 2017, 13 (11)

[5]

BRENNER S, 1974, GENETICS, V77, P71

[6] Dendro-dendritic bundling and shared synapses between gonadotropin-releasing hormone neurons [J].

Campbell, Rebecca E. ;

Gaidamaka, Galina ;

Han, Seong-Kyu ;

Herbison, Allan E. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (26) :10835-10840

[7] Cytoskeletal dynamics and transport in growth cone motility and axon guidance [J].

Dent, EW ;

Gertler, FB .

NEURON, 2003, 40 (02) :209-227

[8]

Díaz-Balzac CA, 2016, CURR BIOL, V26, P2379, DOI [10.1016/j.cub.2016.07.008, 10.1016/j.cub.2016.07.078]

[9] An Extracellular Adhesion Molecule Complex Patterns Dendritic Branching and Morphogenesis [J].

Dong, Xintong ;

Liu, Oliver W. ;

Howell, Audrey S. ;

Shen, Kang .

CELL, 2013, 155 (02) :296-307

[10]

Forrester WC, 1997, DEVELOPMENT, V124, P1831

← 1 2 3 4 →