The role of serum-free light chain ratios in the prediction of poor prognosis in multiple myeloma patients: a systematic review and meta-analysis

被引:1
作者
Cao, Dan [1 ]
Shou, Lihong [1 ]
Wu, Ying [1 ]
Dong, Xiaohui [1 ]
机构
[1] Huzhou Univ, Huzhou Cent Hosp, Dept Hematol, Affiliated Cent Hosp, Huzhou, Peoples R China
关键词
Serum-free light chains ratio; prognosis; multiple myeloma; meta-analysis; STEM-CELL TRANSPLANTATION; KAPPA/LAMBDA RATIO; IMPACT;
D O I
10.1080/16078454.2022.2127460
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background The association between the serum free light chain (sFLC) ratio and the prognosis of multiple myeloma (MM) patients is controversial. Aim The purpose of this study is to explore the relationship between the sFLC ratio and the prognosis of MM patients through meta-analysis. Methods Online public databases were searched to find relevant studies. The retrieval time is limited from the establishment of the database to July 2021. The overall survival (OS) and progression-free survival (PFS) rates were compared. The results were described using hazard ratio (HR) and a 95% confidence interval (CI). Qualitative studies were also included. Results A total of 9 studies involving 2864 participants were included. A pooled analysis based on four studies including newly-diagnosed MM patients, demonstrated that an abnormal sFLC ratio was associated with poor outcomes of OS (HR = 1.82, 95% CI: 1.15-2.90) and PFS (HR = 1.87, 95% CI: 1.20-2.90). Three qualitative studies showed that an abnormal sFLC ratio was related with poor outcomes of OS (studies all included newly diagnosed MM patients) and PFS (two studies included newly-diagnosed MM patients and one study included non-newly-diagnosed MM patients). Two studies stated that the sFLC ratio is not associated with OS (both studies included non-newly-diagnosed MM patients) and one study reported that the sFLC ratio is not associated with PFS (study included non-newly-diagnosed MM patients). Conclusion sFLC ratio could be used to predict adverse outcomes in newly-diagnosed MM patients, but is not suitable for non-newly-diagnosed MM patients.
引用
收藏
页码:1130 / 1139
页数:10
相关论文
共 29 条
  • [1] Utility of serum free light chain ratio in response definition in patients with multiple myeloma
    Abdallah, Nadine
    Kapoor, Prashant
    Murray, David L.
    Buadi, Francis K.
    Dingli, David
    Dispenzieri, Angela
    Gertz, Morie A.
    Go, Ronald S.
    Gonsalves, Wilson I.
    Hayman, Suzanne R.
    Kourelis, Taxiarchis V.
    Lacy, Martha Q.
    Leung, Nelson
    Lust, John A.
    Muchtar, Eli
    Warsame, Rahma
    Kyle, Robert A.
    Rajkumar, S. Vincent
    Kumar, Shaji K.
    [J]. BLOOD ADVANCES, 2020, 4 (02) : 322 - 326
  • [2] Randomized clinical trial of zoledronic acid in multiple myeloma patients undergoing high-dose chemotherapy and stem-cell transplantation
    Aviles, A.
    Neri, N.
    Huerta-Guzman, J.
    Nambo, M. J.
    [J]. CURRENT ONCOLOGY, 2013, 20 (01) : E13 - E20
  • [3] Uncovering the biology of multiple myeloma among African Americans: a comprehensive genomics approach
    Baker, Angela
    Braggio, Esteban
    Jacobus, Susanna
    Jung, Sungwon
    Larson, Dirk
    Therneau, Terry
    Dispenzieri, Angela
    Van Wier, Scott A.
    Ahmann, Gregory
    Levy, Joan
    Perkins, Louise
    Kim, Seungchan
    Henderson, Kimberly
    Vesole, David
    Rajkumar, S. Vincent
    Jelinek, Diane F.
    Carpten, John
    Fonseca, Rafael
    [J]. BLOOD, 2013, 121 (16) : 3147 - 3152
  • [4] Bustoros Mark, 2017, Am Soc Clin Oncol Educ Book, V37, P548, DOI 10.14694/EDBK_175175
  • [5] High-dose chemotherapy plus autologous stem-cell transplantation as consolidation therapy in patients with relapsed multiple myeloma after previous autologous stem-cell transplantation (NCRI Myeloma X Relapse [Intensive trial]): a randomised, open-label, phase 3 trial
    Cook, Gordon
    Williams, Cathy
    Brown, Julia M.
    Cairns, David A.
    Cavenagh, Jamie
    Snowden, John A.
    Ashcroft, A. John
    Fletcher, Marie
    Parrish, Chris
    Yong, Kwee
    Cavet, Jim
    Hunter, Hanna
    Bird, Jenny M.
    Chalmers, Anna
    O'Connor, Sheila
    Drayson, Mark T.
    Morris, Treen C. M.
    [J]. LANCET ONCOLOGY, 2014, 15 (08) : 874 - 885
  • [6] Multiple myeloma clonal evolution in homogeneously treated patients
    Corre, Jill
    Cleynen, Alice
    du Pont, Sebastien Robiou
    Buisson, Laure
    Bolli, Niccolo
    Attal, Michel
    Munshi, Nikhil
    Avet-Loiseau, Herve
    [J]. LEUKEMIA, 2018, 32 (12) : 2636 - 2647
  • [7] Prognostic Value of Serum Free Light Chains Measurements in Multiple Myeloma Patients
    de Veas Silva, Jose Luis Garcia
    Guitarte, Carmen Bermudo
    Valladares, Paloma Menendez
    Rojas Noboa, Johanna Carolina
    Kestler, Krysta
    Millan, Rafael Duro
    [J]. PLOS ONE, 2016, 11 (11):
  • [8] Serum free light chains, not urine specimens, should be used to evaluate response in light-chain multiple myeloma
    Dejoie, Thomas
    Corre, Jill
    Caillon, Helene
    Hulin, Cyrille
    Perrot, Aurore
    Caillot, Denis
    Boyle, Eileen
    Chretien, Marie-Lorraine
    Fontan, Jean
    Belhadj, Karim
    Brechignac, Sabine
    Decaux, Olivier
    Voillat, Laurent
    Rodon, Philippe
    Fitoussi, Olivier
    Araujo, Carla
    Benboubker, Lotfi
    Fontan, Charlotte
    Tiab, Mourad
    Godmer, Pascal
    Luycx, Odile
    Allangba, Olivier
    Pignon, Jean-Michel
    Fuzibet, Jean-Gabriel
    Legros, Laurence
    Stoppa, Anne Marie
    Dib, Mamoun
    Pegourie, Brigitte
    Orsini-Piocelle, Frederique
    Karlin, Lionel
    Arnulf, Bertrand
    Roussel, Murielle
    Garderet, Laurent
    Mohty, Mohamad
    Meuleman, Nathalie
    Doyen, Chantal
    Lenain, Pascal
    Macro, Margaret
    Leleu, Xavier
    Facon, Thierry
    Moreau, Philippe
    Attal, Michel
    Avet-Loiseau, Herve
    [J]. BLOOD, 2016, 128 (25) : 2941 - 2948
  • [9] Serum-free light chains combined with the Revised International Staging System could further distinguish the superior and inferior clinical outcome of multiple myeloma patients
    Du, Juan
    Lu, Jing
    Gao, Wen
    Liu, Jin
    He, Haiyan
    Li, Lu
    Li, Rong
    Zhou, Lili
    Jiang, Hua
    Chen, Wenming
    Fu, Weijun
    Hou, Jian
    [J]. ANNALS OF HEMATOLOGY, 2020, 99 (08) : 1779 - 1791
  • [10] Serum Free Light Chain Ratio, Total κ/λ Ratio, and Immunofixation Results Are Not Prognostic Factors after Stem Cell Transplantation for Newly Diagnosed Multiple Myeloma
    Giarin, Manuela M.
    Giaccone, Luisa
    Sorasio, Roberto
    Sfiligoi, Christian
    Amoroso, Barbara
    Cavallo, Federica
    Cipriani, Alessia
    Palumbo, Antonio
    Boccadoro, Mario
    [J]. CLINICAL CHEMISTRY, 2009, 55 (08) : 1510 - 1516