Feasibility and safety of using an automated decision support system for insulin therapy in the treatment of steroid-induced hyperglycemia in patients with acute graft-versus-host disease: A randomized trial

被引：6

作者：

Aberer, Felix ^{[1
]}

Mader, Julia K. ^{[1
]}

Holzgruber, Julia ^{[1
]}

Trummer, Christian ^{[1
]}

Schwetz, Verena ^{[1
]}

Pandis, Marlene ^{[1
]}

Pferschy, Peter N. ^{[1
]}

Greinix, Hildegard ^{[2
]}

Tripolt, Norbert J. ^{[1
]}

Pieber, Thomas R. ^{[1
,3
,4
]}

Zebisch, Armin ^{[2
]}

Sill, Heinz ^{[2
]}

Woelfler, Albert ^{[2
,3
]}

Sourij, Harald ^{[1
,3
]}

机构：

[1] Med Univ Graz, Div Endocrinol & Diabetol, Graz, Austria

[2] Med Univ Graz, Div Hematol, Graz, Austria

[3] Ctr Biomarker Res Med CBmed, Graz, Austria

[4] Hlth Inst Biomed & Hlth Sci, Graz, Austria

来源：

JOURNAL OF DIABETES INVESTIGATION | 2019年 / 10卷 / 02期

关键词：

Decision support system; Feasibility trial; Steroid-induced hyperglycemia; BASAL-BOLUS; MANAGEMENT; WORKFLOW; 1ST;

D O I：

10.1111/jdi.12919

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Steroid-induced hyperglycemia (SIHG) has shown to independently increase the risk for mortality in patients with acute graft-versus-host disease, and it is still unclear whether SIHG might be a modifiable risk factor. Therefore, a feasibility trial was carried out aiming to evaluate the performance of a standardized decision support system (GlucoTab [GT]) for insulin therapy in patients with SIHG. A total of 10 hyperglycemic acute graft-versus-host disease patients were included and treated either with GT or standard of care during hospitalization. Follow-up duration was 6 months. Comparing the GT versus standard of care group, 364 versus 1,020 glucose readings were available during a median of 41 days (interquartile range [IQR] 22-89) and 101 days (IQR 55-147) of hospitalization. The median overall glucose levels were 151 mg/dL (123-192) versus 162 mg/dL (IQR 138-193) for GT and standard of care, respectively (P < 0.001); hypoglycemia rates were comparably low. Treatment of SIHG with an algorithm-based system for subcutaneous insulin was feasible and safe.

引用

页码：339 / 342

页数：4

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