Microinvasive breast cancer and the role of sentinel node biopsy: An institutional experience and review of the literature

被引:38
作者
Guth, Amber A. [1 ]
Mercado, Cecilia [2 ]
Roses, Daniel F.
Darvishian, Farbod [3 ]
Singh, Baljit [3 ]
Cangiarella, Joan F. [3 ]
机构
[1] NYU, Ctr Clin Canc, Sch Med, Dept Surg, New York, NY 10016 USA
[2] NYU, Sch Med, Dept Radiol, New York, NY 10016 USA
[3] NYU, Sch Med, Dept Pathol, New York, NY 10016 USA
关键词
ductal carcinoma in situ; microinvasion; sentinel node biopsy;
D O I
10.1111/j.1524-4741.2008.00594.x
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Ductal carcinoma in situ with microinvasion (DCISM) is a distinct clinicopathologic entity. Its true metastatic potential has been unclear, due in part to historical differences in the definition of microinvasion. The role of routine axillary staging for DCISM is controversial, given the reportedly low incidence of axillary metastases. We describe our institutional experience with DCISM, and define the role of axillary staging. A retrospective analysis was made of patients with DCISM. Forty-four patients underwent axillary staging (24 axillary lymph node dissection [ALND], 22 sentinel node biopsy [SNB]). Macrometastatic disease was present in three patients (7%), and two patients had isolated tumor cells (itc) in the sentinel node. Patients with axillary metastases tended to be younger. Comedonecrosis, nuclear grade, multifocal microinvasion or presentation as a clinical mass was not associated with a higher rate of axillary metastases. In this series, 7% of patients had macrometastatic disease, and two patients (5%) had itc only. Axillary staging is indicated, and SNB is appropriate for the identification of axillary metastatic disease.
引用
收藏
页码:335 / 339
页数:5
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