Exosomes as drug carriers for clinical application

被引：26

作者：

Di, Cuixia ^{[1
,2
]}

Zhang, Qianjing ^{[1
,2
,3
]}

Wang, Yupei ^{[1
,2
,3
]}

Wang, Fang ^{[1
,2
,3
]}

Chen, Yuhong ^{[1
,2
,3
]}

Gan, Lu ^{[1
,2
,3
]}

Zhou, Rong ^{[1
,2
]}

Sun, Chao ^{[1
,2
]}

Li, Hongyan ^{[1
,2
]}

Zhang, Xuetian ^{[1
,2
,3
]}

Yang, Hongying ^{[4
]}

Zhang, Hong ^{[1
,2
,3
]}

机构：

[1] Chinese Acad Sci, Inst Modern Phys, Dept Radiat Med, Lanzhou, Gansu, Peoples R China

[2] Chinese Acad Sci, Key Lab Heavy Ion Radiat Biol & Med, Lanzhou, Gansu, Peoples R China

[3] Univ Chinese Acad Sci, Coll Life Sci, Beijing, Peoples R China

[4] Med Coll Soochow, Sch Radiat Med & Protect, Suzhou, Peoples R China

来源：

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY | 2018年 / 46卷

基金：

中国国家自然科学基金;

关键词：

Exosomes; nanoparticle; tumor; drug carrier; chemotherapy; radiotherapy; EXTRACELLULAR VESICLES; DELIVERY VEHICLES; STROMAL CELLS; CANCER; RESISTANCE; BRAIN; RNA; NANOCARRIERS; PERSPECTIVES; FIBROBLASTS;

D O I：

10.1080/21691401.2018.1501381

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Exosomes are nanoscale vesicles shed from all cell types and play a major role in communication and transportation of materials between cells due to their ability to transfer proteins and nucleic acids from one cell to another. Analogous in size and function to synthetic nanoparticles, exosomes offer many advantages, rendering them the most promising candidates for targeted drug or gene delivery vehicles. Exosomes can also induce chemoresistance or radioresistance of tumor cells. Studies about the related mechanisms help overcome cancer therapy resistance to some extent. In this review, we focus on the application of exosomes as nanocarriers and the current status of the application of exosomes to cancer therapy.

引用

页码：S564 / S570

页数：7

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