Epileptic seizures in cerebral venous sinus thrombosis: Subgroup analysis of VENOST study

被引：21

作者：

Uluduz, Derya ^{[1
]}

Midi, Ipek ^{[2
]}

Duman, Taskin ^{[3
]}

Yayla, Vildan ^{[4
]}

Karahan, Ali Yavuz ^{[5
]}

Afsar, Nazire ^{[6
]}

Goksu, Eylem Ozaydin ^{[7
]}

Mengulluoglu, Necdet ^{[8
]}

Aytac, Emrah ^{[9
]}

Sungur, Mehmet Ali ^{[10
]}

Yesilot, Nilufer ^{[11
]}

Ince, Birsen ^{[1
]}

Yalin, Osman Ozgur ^{[12
]}

Oruc, Serdar ^{[13
]}

Senol, Mehmet Guney ^{[14
,22
]}

Yilmaz, Arda ^{[15
]}

Gokce, Mustafa ^{[16
]}

Demirci, Seden ^{[17
,25
]}

Kusbeci, Ozge Yilmaz ^{[18
]}

Uzuner, Gulnur ^{[19
]}

Caglayan, Hale Zeynep Batur ^{[20
]}

Acikgoz, Mustafa ^{[21
]}

Kurucu, Hatice ^{[1
]}

Ozdag, Fatih ^{[22
]}

Baybas, Sevim ^{[23
]}

Ekmekci, Hakan ^{[24
]}

Cabala, Murat ^{[4
]}

Yaman, Mehmet ^{[13
]}

Yurekli, Vedat Ali ^{[25
]}

Tekeli, Hakan ^{[22
,26
]}

Genc, Hamit ^{[15
]}

Utku, Uygar ^{[16
]}

Sahin, Sevki ^{[27
]}

Tokuc, Firdevs Ezgi Ucan ^{[7
]}

Uzuner, Nevzat ^{[19
]}

Bektas, Hesna ^{[28
]}

Kablan, Yuksel ^{[29
]}

Goksel, Basak Karakurum ^{[30
]}

Milanlioglu, Aysel ^{[31
]}

Orken, Dilek Necioglu ^{[32
]}

Aluclu, Ufuk ^{[33
]}

Colakoglu, Sena ^{[3
]}

Tufekci, Ahmet ^{[34
]}

Bakar, Mustafa ^{[35
]}

Nazliel, Bijen ^{[20
]}

Tascilar, Nida ^{[21
]}

Goksan, Baki ^{[1
]}

Kozak, Hasan Huseyin ^{[36
]}

Demir, Serkan ^{[22
,26
]}

Misirli, Cemile Handan ^{[37
]}

机构：

[1] Istanbul Univ Cerrahpasa, Cerrahpasa Med Sch, Dept Neurol, Istanbul, Turkey

[2] Marmara Univ, Sch Med, Dept Neurol, Istanbul, Turkey

[3] Mustafa Kemal Univ, Sch Med, Dept Neurol, Antakya, Turkey

[4] Saglik Bilimleri Univ, Bakirkoy Sadi Konuk Res & Training Hosp, Neurol Clin, Istanbul, Turkey

[5] Usak Univ, Sch Med, Dept Phys Med & Rehabil, Usak, Turkey

[6] Acibadem Mehmet Aydinlar Univ, Dept Neurol, Istanbul, Turkey

[7] Antalya Res & Training Hosp, Neurol Clin, Antalya, Turkey

[8] Eskisehir Govt Hosp, Neurol Clin, Eskisehir, Turkey

[9] Firat Univ, Sch Med, Dept Neurol, Elazig, Turkey

[10] Duzce Univ, Sch Med, Dept Biostat, Duzce, Turkey

[11] Istanbul Univ, Sch Med, Dept Neurol, Istanbul, Turkey

[12] Saglik Bilimleri Univ, Istanbul Res & Training Hosp, Neurol Clin, Istanbul, Turkey

[13] Afyon Kocatepe Univ, Sch Med, Dept Neurol, Afyon, Turkey

[14] Sisli Hamidiye Res & Training Hosp, Neurol Clin, Istanbul, Turkey

[15] Mersin Univ, Dept Neurol, Sch Med, Mersin, Turkey

[16] Sutcu Imam Univ, Sch Med, Dept Neurol, Kahramanmaras, Turkey

[17] Aspendos Anatolian Hosp, Dept Neurol, Antalya, Turkey

[18] Bozyaka Res & Training Hosp, Neurol Clin, Izmir, Turkey

[19] Osmangazi Univ, Sch Med, Dept Neurol, Eskisehir, Turkey

[20] Gazi Univ, Sch Med, Dept Neurol, Ankara, Turkey

[21] Bulent Ecevit Univ, Sch Med, Dept Neurol, Zonguldak, Turkey

[22] Saglik Bilimleri Univ, Sultan Abdulhamid Han Res & Training Hosp, Neurol Clin, Istanbul, Turkey

[23] Bakirkoy Res & Training Hosp Neurol & Psychiat Di, Neurol Clin, Istanbul, Turkey

[24] Selcuk Univ, Sch Med, Dept Neurol, Konya, Turkey

[25] Suleyman Demirel Univ, Sch Med, Dept Neurol, Isparta, Turkey

[26] Sancaktepe Res & Training Hosp, Neurol Clin, Istanbul, Turkey

[27] Maltepe Univ, Sch Med, Dept Neurol, Istanbul, Turkey

[28] Ataturk Training & Res Hosp, Neurol Clin, Ankara, Turkey

[29] Inonu Univ, Sch Med, Dept Neurol, Malatya, Turkey

[30] Baskent Univ, Sch Med, Dept Neurol, Adana, Turkey

[31] Yuzuncu Yil Univ, Sch Med, Dept Neurol, Van, Turkey

[32] Demiroglu Bilim Univ, Dept Neurol, Istanbul, Turkey

[33] Dicle Univ, Sch Med, Dept Neurol, Diyarbakir, Turkey

[34] Recep Tayyip Erdogan Univ, Sch Med, Dept Neurol, Rize, Turkey

[35] Uludag Univ, Sch Med, Dept Neurol, Bursa, Turkey

[36] Necmettin Erbakan Univ, Sch Med, Dept Neurol, Konya, Turkey

[37] Saglik Bilimleri Univ, Haydarpasa Numune Res & Training Hosp, Clin Neurol, Istanbul, Turkey

[38] Erenkoy Res, Training Hosp Neurol & Psychiat Dis, Clin Neurol, Istanbul, Turkey

来源：

SEIZURE-EUROPEAN JOURNAL OF EPILEPSY | 2020年 / 78卷

关键词：

Cerebrovascular disease; Cerebral venous sinus thrombosis; Epilepsy; Early seizure; RISK-FACTORS; VEIN; PUERPERIUM; PREGNANCY;

D O I：

10.1016/j.seizure.2020.02.017

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Purpose: The aim of this study is to evaluate the presence and prognostic impact of early seizures in cerebral venous sinus thrombosis patients (CVST). Method: VENOST is a retrospective and prospective national multicenter observational study. CVST patients with or without epileptic seizures (ES) were analyzed and compared in terms of demographic and imaging data, causative factors, clinical variables, and prognosis in a total of 1126 patients. Results: The mean age of the patients in the ES group was 39.73 +/- 12.64 and 40.17 +/- 14.02 years in the non-ES group (p > 0.05). Epileptic seizures were more common (76.6 %) in females (p < 0.001). Early ES occurred in 269 of 1126 patients (23.9 %). Epileptic seizures mainly presented in the acute phase (71.4 %) of the disease (p < 0.001). Majority of these (60.5 %) were in the first 24 h of the CVST. The most common neurological signs were focal neurologic deficits (29.9 %) and altered consciousness (31.4 %) in the ES group. Superior sagittal sinus (SSS) and cortical veins (CV) involvement were the most common sites of thrombosis and the mostly related etiology were found puerperium in seizure group (30.3 % vs 13.9 %). Patients with seizures had worse outcome in the first month of the disease (p < 0.001) but these did not have any influence thereafter. Conclusions: In this largest CVST cohort (VENOST) reported female sex, presence of focal neurological deficits and altered consciousness, thrombosis of the SSS and CVs, hemorrhagic infarction were risk factors for ES occurrence in patients with CVST.

引用

页码：113 / 117

页数：5

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