Novel Schiff base ligands derived from Cinchona alkaloids for Cu(II)-catalyzed asymmetric Henry reaction

被引：46

作者：

Wei, Yu ^{[1
]}

Yao, Lin ^{[1
]}

Zhang, Bangle ^{[2
]}

He, Wei ^{[1
]}

Zhang, Shengyong ^{[1
]}

机构：

[1] Fourth Mil Med Univ, Sch Pharm, Dept Chem, Xian 710032, Shaanxi Provinc, Peoples R China

[2] Fourth Mil Med Univ, Sch Pharm, Dept Pharmaceut, Xian 710032, Shaanxi Provinc, Peoples R China

来源：

TETRAHEDRON | 2011年 / 67卷 / 44期

基金：

中国国家自然科学基金;

关键词：

Henry reaction; Schiff base ligands; Copper complexes; Asymmetric catalysis; Cinchona alkaloids; ENANTIOSELECTIVE NITROALDOL REACTION; THIOUREA BIFUNCTIONAL ORGANOCATALYST; CHIRAL COPPER-COMPLEXES; AMINO ALCOHOL; CATALYSIS; EFFICIENT; SALT; DERIVATIVES; ALDEHYDES; BIS(THIAZOLINE);

D O I：

10.1016/j.tet.2011.08.076

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new series of Schiff bases derived from Cinchona alkaloids were developed as chiral ligands for the copper(II)-catalyzed asymmetric Henry reaction. The optimized catalyst can promote the Henry reaction of both aromatic and aliphatic aldehydes with nitromethane or nitroethane. Those reactions can afford the chiral beta-nitro alcohol adducts with high enantioselectivities. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：8552 / 8558

页数：7

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