Linkage of asthma and total serum IgE concentration to markers on chromosome 12q: Evidence from Afro-Caribbean and Caucasian populations

被引：196

作者：

Barnes, KC

Neely, JD

Duffy, DL

Freidhoff, LR

Breazeale, DR

Schou, C

Naidu, RP

Levett, PN

Renault, B

Kucherlapati, R

Iozzino, S

Ehrlich, E

Beaty, TH

Marsh, DG

机构：

[1] JOHNS HOPKINS UNIV, SCH MED, DEPT MED, DIV CLIN IMMUNOL, BALTIMORE, MD 21205 USA

[2] JOHNS HOPKINS UNIV, SCH MED, GRAD PROGRAM CELLULAR & MOL MED, BALTIMORE, MD 21205 USA

[3] JOHNS HOPKINS UNIV, SCH HYG & PUBL HLTH, DEPT EPIDEMIOL, BALTIMORE, MD 21205 USA

[4] ALK LABS, HORSHOLM, DENMARK

[5] UNIV W INDIES, FAC MED, KINGSTON, JAMAICA

[6] ALBERT EINSTEIN COLL MED, DEPT MOL GENET, BRONX, NY 10467 USA

来源：

GENOMICS | 1996年 / 37卷 / 01期

关键词：

D O I：

10.1006/geno.1996.0518

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

To identify genes potentially relevant in atopic asthma, we analyzed markers in chromosome 12q15-q24.1 for linkage to asthma and total serum IgE concentration. Sib-pair analyses of 10 markers in 345 full- and 219 half-sib pairs from 29 multiplex Afro-Caribbean families provided evidence for linkage to this region for both asthma and total serum IgE. Certain alleles at these loci showed significant evidence of transmission disequilibrium with both asthma and high IgE. Using 6 of these markers and 11 additional markers, evidence for linkage of total IgE to 12q was also found in 12 Caucasian Amish kindreds (24 nuclear families) by both sib-pair and transmission disequilibrium analyses. These findings suggest that the 12q15-q24.1 region may contain a gene(s) controlling asthma and the associated ''high total IgE'' trait. (C) 1996 Academic Press, Inc.

引用

页码：41 / 50

页数：10

共 68 条

[1] MOLECULAR-CLONING OF MAST-CELL GROWTH-FACTOR, A HEMATOPOIETIN THAT IS ACTIVE IN BOTH MEMBRANE-BOUND AND SOLUBLE FORMS [J].