Urinary phthalate metabolites are associated with insulin resistance in obese subjects

被引：46

作者：

Dirinck, Eveline ^{[1
,2
]}

Dirtu, Alin C. ^{[3
]}

Geens, Tinne ^{[3
]}

Covaci, Adrian ^{[3
]}

Van Gaal, Luc ^{[1
,2
]}

Jorens, Philippe G. ^{[4
]}

机构：

[1] Univ Antwerp Hosp, Dept Endocrinol Diabetol & Metab, Edegem, Belgium

[2] Univ Antwerp, B-2020 Antwerp, Belgium

[3] Univ Antwerp, Toxicol Ctr, B-2020 Antwerp, Belgium

[4] Univ Antwerp Hosp, Dept Clin Pharmacol, Edegem, Belgium

来源：

ENVIRONMENTAL RESEARCH | 2015年 / 137卷

关键词：

Phthalates; Obesity; Diabetes; Insulin resistance; Beta-cell function; Oral glucose tolerance test; WAIST CIRCUMFERENCE; NATIONAL-HEALTH; EXPOSURE; POLLUTANTS; CHEMICALS; GLUCOSE;

D O I：

10.1016/j.envres.2015.01.010

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Phthalates are potentially involved in the development of type 2 diabetes mellitus. In a cohort of 123 obese subjects, 10 phthalate metabolites were analyzed. An oral glucose tolerance test was performed and various estimates of insulin resistance and beta-cell function were calculated. After adjustment for age, physical activity level, smoking behavior, medication use and body mass index, several phthalate metabolites were linked to markers of glucose tolerance and insulin resistance. (C) 2015 Elsevier Inc. All rights reserved.

引用

页码：419 / 423

页数：5

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