Norovirus detection in wastewater and its correlation with human gastroenteritis: a systematic review and meta-analysis

被引：41

作者：

Huang, Yue ^{[1
,2
]}

Zhou, Nan ^{[1
,2
]}

Zhang, Shihan ^{[1
,2
]}

Yi, Youqin ^{[1
,2
]}

Han, Ying ^{[1
,2
]}

Liu, Minqi ^{[1
,2
]}

Han, Yue ^{[1
,2
]}

Shi, Naiyang ^{[1
,2
]}

Yang, Liuqing ^{[1
,2
]}

Wang, Qiang ^{[1
,2
]}

Cui, Tingting ^{[1
,2
]}

Jin, Hui ^{[1
,2
]}

机构：

[1] Southeast Univ, Sch Publ Hlth, Dept Epidemiol & Hlth Stat, Nanjing 210009, Peoples R China

[2] Southeast Univ, Sch Publ Hlth, Key Lab Environm Med Engn, Minist Educ, Nanjing 210009, Peoples R China

来源：

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH | 2022年 / 29卷 / 16期

基金：

中国国家自然科学基金;

关键词：

Wastewater surveillance; Norovirus; Human gastroenteritis; Detection; Meta-analysis; Systematic review; HUMAN ENTERIC VIRUSES; MEMBRANE BIOREACTOR MBR; SEWAGE-TREATMENT PLANTS; RIO-DE-JANEIRO; MOLECULAR CHARACTERIZATION; ENVIRONMENTAL SURVEILLANCE; RECOMBINANT GII.P16-GII.2; PATHOGENIC VIRUSES; GII.17; NOROVIRUS; GENOGROUP IV;

D O I：

10.1007/s11356-021-18202-x

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Norovirus (NoV) is a major cause of sporadic cases and outbreaks of acute gastroenteritis (AGE), thereby imposing threat to health globally. It is unclear how quantitation of wastewater NoV reflects the incidence of human AGE infections; therefore, we conducted this systematic review and meta-analysis of published NoV wastewater surveillance studies. A literature search was performed, and all studies on NoV wastewater surveillance were identified. Quantitative results were evaluated. The results showed that the overall detection rate of NoV in wastewater was 82.10% (95% confidence interval [CI]: 74.22-89.92%); NoV concentration was statistically significant in terms of season (P < 0.001), with higher concentration in spring and winter. There were positive correlations between NoV GII concentration in wastewater and GII AGE cases (r(s) = 0.51, 95% CI: 0.18-0.74, I-2 = 0%), total AGE cases (r(s) = 0.40, 95% CI: 0.15-0.61, I-2 = 23%) and NoV outbreaks (r(s) = 0.47, 95% CI: 0.30-0.62, I-2 = 0%). Results of cross-correlation analysis of partial data indicated that variations in GII concentration were consistent with or ahead of those in the number of AGE cases. The diversity of NoV genotypes in wastewater was elucidated, and the dominant strains in wastewater showed a consistent temporal distribution with those responsible for human AGE. Our study demonstrated the potential association of NoV detected in wastewater with AGE infections, and further studies are needed to confirm this conclusion.

引用

页码：22829 / 22842

页数：14