How to Manage Withdrawal of Sedation and Analgesia in Mechanically Ventilated COVID-19 Patients?

被引：10

作者：

Ego, Amedee ^{[1
]}

Halenarova, Katarina ^{[1
]}

Creteur, Jacques ^{[1
]}

Taccone, Fabio Silvio ^{[1
]}

机构：

[1] Univ Libre Bruxelles ULB, Erasme Hosp, Dept Intens Care, B-1070 Brussels, Belgium

来源：

JOURNAL OF CLINICAL MEDICINE | 2021年 / 10卷 / 21期

关键词：

sedation; analgesia; COVID-19; withdrawal; management; KETAMINE;

D O I：

10.3390/jcm10214917

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

COVID-19 patients suffering from severe acute respiratory distress syndrome (ARDS) require mechanical ventilation (MV) for respiratory failure. To achieve these ventilatory goals, it has been observed that COVID-19 patients in particular require high regimens and prolonged use of sedatives, analgesics and neuromuscular blocking agents (NMBA). Withdrawal from analgo-sedation may induce a "drug withdrawal syndrome " (DWS), i.e., clinical symptoms of anxiety, tremor, agitation, hallucinations and vomiting, as a result of adrenergic activation and hyperalgesia. We describe the epidemiology, mechanisms leading to this syndrome and our strategies to prevent and treat it.

引用

页数：8

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