Nickel-Catalyzed Intramolecular Hydroalkenylation of Imines

被引：14
作者：
Feng, Wei-Min [1 ,2 ]
Li, Tian-Yu [1 ,2 ]
Xiao, Li-Jun [1 ,2 ]
Zhou, Qi-Lin [1 ,2 ]
机构：
[1] Nankai Univ, Coll Chem, State Key Lab, Tianjin 300071, Peoples R China
[2] Nankai Univ, Coll Chem, Inst Elementoorgan Chem, Tianjin 300071, Peoples R China
来源：
ORGANIC LETTERS | 2021年 / 23卷 / 20期
基金：
中国国家自然科学基金;
关键词：
OXIDATIVE CYCLIZATION; AZA-NICKELACYCLE; ALDEHYDES; ALKYNES; ALKENES; LIGAND; TRANSFORMATION; ETA(2)-ALKENE; INTERMEDIATE; STYRENES;
D O I：
10.1021/acs.orglett.1c02908
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A ligand-enabled nickel-catalyzed intramolecular hydroalkenylation of imines with unactivated alkenes has been developed. A variety of five- and six-membered cyclic allylic amines were synthesized in high yields. The use of both wide-bite-angle diphosphine ligand and Bronsted acid is crucial for realizing the reaction. Preliminary investigation of the asymmetric intramolecular hydroalkenylation of imines shows promising potential for the application of the method in the synthesis of enantio-enriched cyclic allylic amines.
引用
收藏
页码：7900 / 7904
页数：5
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