Antimicrobial Activities of Chitosan Derivatives

被引：27

作者：

Ardean, Cristina ^{[1
]}

Davidescu, Corneliu Mircea ^{[2
]}

Nemes, Nicoleta Sorina ^{[2
]}

Negrea, Adina ^{[1
]}

Ciopec, Mihaela ^{[1
]}

Duteanu, Narcis ^{[1
]}

Negrea, Petru ^{[1
]}

Duda-Seiman, Daniel ^{[3
]}

Muntean, Delia ^{[4
]}

机构：

[1] Politehn Univ Timisoara, Fac Ind Chem & Environm Engn, 2 Piata Victoriei, Timisoara 300006, Romania

[2] Univ Politehn Timisoara, Renewable Energy Res Inst ICER, 138 Gavril Musicescu St, Timisoara 300501, Romania

[3] Victor Babes Univ Med & Pharm Timisoara, Dept Cardiol, 2 Piata Eftimie Murgu, Timisoara 300041, Romania

[4] Victor Babes Univ Med & Pharm Timisoara, Dept Microbiol, Multidisciplinary Res Ctr Antimicrobial Resistanc, 2 Eftimie Murgu Sq, Timisoara 300041, Romania

来源：

PHARMACEUTICS | 2021年 / 13卷 / 10期

关键词：

chitosan; antibacterial activities; antifungal activities; functionalization by impregnation; ATOMIC-FORCE MICROSCOPY; ANTIBACTERIAL ACTIVITY; MOLECULAR-WEIGHT; THIOUREA DERIVATIVES; ESCHERICHIA-COLI; OUTER-MEMBRANE; ANTIFUNGAL; ANTIOXIDANT; 2-MERCAPTOBENZOTHIAZOLE; OPPORTUNITIES;

D O I：

10.3390/pharmaceutics13101639

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Considering the challenge created by the development of bacterial and fungal strains resistant to multiple therapeutic variants, new molecules and materials with specific properties against these microorganisms can be synthesized, like those synthesized from biopolymers such as chitosan with improved antimicrobial activities. Antimicrobial activities of seven obtained materials were tested on four reference strains belonging to American Type Culture Collection. The best antimicrobial activity was obtained by functionalization by impregnation of chitosan with quaternary ammonium salts, followed by that obtained by functionalization of chitosan with phosphonium. The lowest antibacterial and antifungal effects were expressed by Ch-THIO and Ch-MBT, but new materials obtained with these extractants may be precursors with a significant role in the direct control of active molecules, such as cell growth factors or cell signaling molecules.

引用

页数：21

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