COVID-19 in children. II: Pathogenesis, disease spectrum and management

被引：77

作者：

Howard-Jones, Annaleise R. ^{[1
,2
]}

Burgner, David P. ^{[10
,11
,12
]}

Crawford, Nigel W. ^{[11
,12
,15
]}

Goeman, Emma ^{[3
]}

Gray, Paul E. ^{[4
,5
]}

Hsu, Peter ^{[1
,6
]}

Kuek, Stephanie ^{[16
]}

McMullan, Brendan J. ^{[4
,5
]}

Tosif, Shidan ^{[11
,12
,15
]}

Wurzel, Danielle ^{[11
,13
,16
]}

Bowen, Asha C. ^{[17
,18
]}

Danchin, Margie ^{[11
,12
,15
]}

Koirala, Archana ^{[1
,8
,9
]}

Sharma, Ketaki ^{[1
,8
]}

Yeoh, Daniel K. ^{[14
,17
]}

Britton, Philip N. ^{[1
,7
]}

机构：

[1] Univ Sydney, Childrens Hosp Westmead, Discipline Child & Adolescent Hlth, Westmead, NSW 2145, Australia

[2] Nepean Hosp, NSW Hlth Pathol Nepean, Sydney, NSW, Australia

[3] Royal Prince Alfred Hosp, Dept Infect Dis & Microbiol, Sydney, NSW, Australia

[4] Sydney Childrens Hosp, Dept Immunol & Infect Dis, Sydney, NSW, Australia

[5] Univ New South Wales, Sch Womens & Childrens Hlth, Sydney, NSW, Australia

[6] Childrens Hosp Westmead, Dept Immunol, Sydney, NSW, Australia

[7] Childrens Hosp Westmead, Dept Infect Dis & Microbiol, Sydney, NSW, Australia

[8] Childrens Hosp Westmead, Natl Ctr Immunisat Res & Surveillance, Sydney, NSW, Australia

[9] Nepean Hosp, Dept Infect Dis, Penrith, NSW, Australia

[10] Royal Childrens Hosp, Dept Gen Med, Infect Dis Unit, Melbourne, Vic, Australia

[11] Murdoch Childrens Res Inst, Infect & Immun Theme, Melbourne, Vic, Australia

[12] Univ Melbourne, Dept Paediat, Melbourne, Vic, Australia

[13] Univ Melbourne, Sch Populat & Global Hlth, Melbourne, Vic, Australia

[14] Univ Melbourne, Sir Peter MacCallum Dept Oncol, Melbourne, Vic, Australia

[15] Royal Childrens Hosp, Dept Gen Med, Melbourne, Vic, Australia

[16] Royal Childrens Hosp, Dept Resp & Sleep Med, Melbourne, Vic, Australia

[17] Perth Childrens Hosp, Dept Infect Dis, Perth, WA, Australia

[18] Univ Western Australia, Telethon Kids Inst, Wesfarmers Ctr Vaccines & Infect Dis, Perth, WA, Australia

来源：

JOURNAL OF PAEDIATRICS AND CHILD HEALTH | 2022年 / 58卷 / 01期

关键词：

COVID-19; management; PIMS-TS; SARS-CoV-2; virology; SARS-COV-2; INFECTION; ADOLESCENTS;

D O I：

10.1111/jpc.15811

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

The global disruption of the COVID-19 pandemic has impacted the life of every child either directly or indirectly. This review explores the pathophysiology, immune response, clinical presentation and treatment of COVID-19 in children, summarising the most up-to-date data including recent developments regarding variants of concern. The acute infection with SARS-CoV-2 is generally mild in children, whilst the post-infectious manifestations, including paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS) and 'long COVID' in children, are more complex. Given that most research on COVID-19 has focused on adult cohorts and that clinical manifestations, treatment availability and impacts differ markedly in children, research that specifically examines COVID-19 in children needs to be prioritised.

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页码：46 / 53

页数：8

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